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William James Kent (born February 10, 1960) is an American
research scientist A scientist is a person who conducts scientific research to advance knowledge in an area of the natural sciences. In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engaged in the philosophic ...
and
computer programmer A computer programmer, sometimes referred to as a software developer, a software engineer, a programmer or a coder, is a person who creates computer programs — often for larger computer software. A programmer is someone who writes/create ...
. He has been a contributor to
genome In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding gen ...
database projects and the 2003 winner of the Benjamin Franklin Award.


Early life

Kent was born in
Hawaii Hawaii ( ; haw, Hawaii or ) is a U.S. state, state in the Western United States, Western United States, located in the Pacific Ocean about from the U.S. mainland. It is the only U.S. state outside North America, the only state that is ...
and grew up in
San Francisco, California San Francisco (; Spanish for " Saint Francis"), officially the City and County of San Francisco, is the commercial, financial, and cultural center of Northern California. The city proper is the fourth most populous in California and 17th ...
,
United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territo ...
.


Computer animation

Kent began his programming career in 1983 with Island Graphics Inc. where he wrote the Aegis Animator program for the
Amiga Amiga is a family of personal computers introduced by Commodore in 1985. The original model is one of a number of mid-1980s computers with 16- or 32-bit processors, 256 KB or more of RAM, mouse-based GUIs, and significantly improved graphi ...
home computer. This program combined polygon tweening in 3D with simple 2D cel-based animation. In 1985 he founded and ran a software company, Dancing Flame, which adapted the Aegis Animator to the
Atari ST The Atari ST is a line of personal computers from Atari Corporation and the successor to the Atari 8-bit family. The initial model, the Atari 520ST, had limited release in April–June 1985 and was widely available in July. It was the first pers ...
, and created Cyber Paint for that machine. Cyber Paint was a 2D animation program that brought together a wide variety of animation and paint functionality and the delta-compressed animation format developed for CAD-3D. The user could move freely between animation frames and paint arbitrarily, or utilize various animation tools for automatic tweening movement across frames. Cyber Paint was one of the first, if not the first, consumer program that enabled the user to paint across time in a compressed digital video format. Later he developed a similar program, the
Autodesk Animator Autodesk Animator is a 2D computer animation and painting program published in 1989 for MS-DOS. It was considered groundbreaking when initially released.
for
PC compatible IBM PC compatible computers are similar to the original IBM PC, XT, and AT, all from computer giant IBM, that are able to use the same software and expansion cards. Such computers were referred to as PC clones, IBM clones or IBM PC clones. ...
s, where the image compression improved to the point it could play off of hard disk, and one could paint using "inks" that performed algorithmic transformations such as smoothing, transparency, and tiled patterns. The Autodesk Animator was used to create artwork for a wide variety of video games.


Involvement with the Human Genome Project

In 2000, he wrote a program, GigAssembler, that allowed the publicly funded
Human Genome Project The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a ph ...
to assemble and publish the first human genome sequence. His efforts were motivated by the research needs of himself and his colleagues, but also out of concern that the data might be made proprietary via patents by
Celera Genomics Celera is a subsidiary of Quest Diagnostics which focuses on genetic sequencing and related technologies. It was founded in 1998 as a business unit of Applera, spun off into an independent company in 2008, and finally acquired by Quest Diagnosti ...
. In their close race with Celera, Kent and the UCSC Professor
David Haussler David Haussler (born 1953) is an American bioinformatician known for his work leading the team that assembled the first human genome sequence in the race to complete the Human Genome Project and subsequently for comparative genome analysis that d ...
quickly built a modest cluster of 50 commodity
personal computer A personal computer (PC) is a multi-purpose microcomputer whose size, capabilities, and price make it feasible for individual use. Personal computers are intended to be operated directly by an end user, rather than by a computer expert or techn ...
s running the
Linux Linux ( or ) is a family of open-source Unix-like operating systems based on the Linux kernel, an operating system kernel first released on September 17, 1991, by Linus Torvalds. Linux is typically packaged as a Linux distribution, which in ...
operating system An operating system (OS) is system software that manages computer hardware, software resources, and provides common daemon (computing), services for computer programs. Time-sharing operating systems scheduler (computing), schedule tasks for ef ...
to run the software. In contrast, Celera was using what was thought then to be one of the most powerful civilian supercomputers in the world. Kent's first assembly on the human genome was released on June 22. Celera finished its assembly three days later on June 25, and the dual results were announced at the
White House The White House is the official residence and workplace of the president of the United States. It is located at 1600 Pennsylvania Avenue NW in Washington, D.C., and has been the residence of every U.S. president since John Adams in 1800 ...
on June 26. On July 7, 2000, the Santa Cruz data was made publicly available on the World Wide Web while the research paper describing this publicly funded genome was published in February 2001 special issue of ''
Nature Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are p ...
'', in parallel with Celera's results in the journal ''
Science Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence for ...
''. In 2002
Tim O'Reilly Tim O'Reilly (born 6 June 1954) is the founder of O'Reilly Media (formerly O'Reilly & Associates). He popularised the terms open source and Web 2.0. Education and early life Born in County Cork, Ireland, Tim O'Reilly moved to San Francisco, Ca ...
described Kent's work as "the most significant work of open source development in the past year". While all of Kent's genomics software is
open source Open source is source code that is made freely available for possible modification and redistribution. Products include permission to use the source code, design documents, or content of the product. The open-source model is a decentralized sof ...
in the sense that the
source code In computing, source code, or simply code, is any collection of code, with or without comments, written using a human-readable programming language, usually as plain text. The source code of a program is specially designed to facilitate the w ...
can be downloaded and read for free, and all of the software can be freely used for academic, nonprofit, and personal use, some of it requires a
license A license (or licence) is an official permission or permit to do, use, or own something (as well as the document of that permission or permit). A license is granted by a party (licensor) to another party (licensee) as an element of an agreeme ...
, either from UCSC or from Kent Informatics Inc., for commercial use. After GigAssembler, Kent went on to write BLAT (BLAST-like alignment tool) and the UCSC Genome Browser to help analyze important genome data. Kent continues to work at UCSC primarily on web tools to help understand the human genome. He helps maintain and upgrade the browser, and has worked on
comparative genomics Comparative genomics is a field of biological research in which the genomic features of different organisms are compared. The genomic features may include the DNA sequence, genes, gene order, regulatory sequences, and other genomic structural la ...
, Parasol, a job control management software for the UCSC kilocluster, and the
ENCODE The Encyclopedia of DNA Elements (ENCODE) is a public research project which aims to identify functional elements in the human genome. ENCODE also supports further biomedical research by "generating community resources of genomics data, software ...
Project.


References


External links


O'Reilly Interview with Jim KentWired article on Jim Kent
{{DEFAULTSORT:Kent, Jim 1960 births Living people American bioinformaticians 21st-century American biologists American computer programmers University of California, Santa Cruz alumni University of California, Santa Cruz faculty Computer animation people Overton Prize winners Human Genome Project scientists