Jerome Phillip Horwitz (January 16, 1919 – September 6, 2012) was an American scientist; his affiliations included the Barbara Ann Karmanos Cancer Institute, the

Wayne State University School of Medicine The Wayne State University School of Medicine (WSUSOM) is the medical school of Wayne State University, a public research university in Detroit, Michigan. It enrolls more than 1,500 students in undergraduate medical education, master's degree, P ...

and the Michigan Cancer Foundation.

Background

Horwitz was a

Jewish Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The ...

Detroit Detroit ( , ; , ) is the largest city in the U.S. state of Michigan. It is also the largest U.S. city on the United States–Canada border, and the seat of government of Wayne County. The City of Detroit had a population of 639,111 at t ...

native and 1937 graduate of Central High School. He earned his bachelor's and master's degrees in chemistry from the

University of Detroit The University of Detroit Mercy is a private Roman Catholic university in Detroit, Michigan. It is sponsored by both the Society of Jesus (Jesuits) and the Sisters of Mercy. The university was founded in 1877 and is the largest Catholic univers ...

; his doctorate in chemistry came from the

University of Michigan , mottoeng = "Arts, Knowledge, Truth" , former_names = Catholepistemiad, or University of Michigania (1817–1821) , budget = $10.3 billion (2021) , endowment = $17 billion (2021)As o ...

. He completed his post-doctoral training at

Northwestern University Northwestern University is a private research university in Evanston, Illinois. Founded in 1851, Northwestern is the oldest chartered university in Illinois and is ranked among the most prestigious academic institutions in the world. Charte ...

and the

Clinical breakthroughs

In 1964, while conducting research for the Michigan Cancer Foundation, Horwitz synthesized a compound that was to become known as

zidovudine Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. It may be used to prevent mother-to-child ...

(AZT) - an antiviral drug used to treat

HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

patients; Zidovudine was initially developed as a treatment for cancer. Horwitz was also first to synthesize

stavudine Stavudine (d4T), sold under the brand name Zerit among others, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use with other antiretrovirals. It may be used for prevention after a needlestick ...

(d4T) and

zalcitabine Zalcitabine (2′-3′-di deoxycytidine, ddC), also called dideoxycytidine, is a nucleoside analog reverse-transcriptase inhibitor (NRTI) sold under the trade name Hivid. Zalcitabine was the third antiretroviral to be approved by the Food and Drug ...

(ddC) - two other

reverse-transcriptase inhibitors Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replicatio ...

used in the treatment of HIV patients. Also during 1964, he published the first production and demonstration of

X-gal X-gal (also abbreviated BCIG for 5-bromo-4-chloro-3-indolyl-β--galactopyranoside) is an organic compound consisting of galactose linked to a substituted indole. The compound was synthesized by Jerome Horwitz and collaborators in 1964. The formal c ...

as a chromogenic substrate. After synthesizing AZT, Horwitz went on to create many successful treatments for cancer and other diseases. At the time of his most recent findings, Horwitz was working for the Michigan Cancer Foundation with a federal grant from the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

; he retired in 2005.

Of further note

*Horwitz was featured in the documentary film ''I am alive today - History of an AIDS drug''. *While some believe Horwitz was referenced in the Captain Underpants books, the Jerome Horwitz Elementary School in the children's book series was in fact named after

Curly Howard Jerome Lester Horwitz (; October 22, 1903 – January 18, 1952), known professionally as Curly Howard, was an American actor and comedian. He was best known as a member of the American comedy team the Three Stooges, which also featured his elder ...

from the

Three Stooges The Three Stooges were an American vaudeville and comedy team active from 1922 until 1970, best remembered for their 190 short subject films by Columbia Pictures. Their hallmark styles were physical farce and slapstick. Six Stooges appeare ...

. (Jerome Horwitz was Curly's given name.)

Sources

FDA press release on AZTKarmanos Cancer Institute formerly Michigan Cancer Foundation

References

{{DEFAULTSORT:Horwitz, Jerome 1919 births 2012 deaths Scientists from Detroit Jewish American scientists University of Detroit Mercy alumni University of Michigan alumni Northwestern University alumni Wayne State University faculty Central High School (Detroit) alumni 21st-century American Jews