Jue Chen () is a Chinese-born American

structural biologist Structural biology is a field that is many centuries old which, and as defined by the Journal of Structural Biology, deals with structural analysis of living material (formed, composed of, and/or maintained and refined by living cells) at every le ...

and

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

. She is the William E. Ford professor of biochemistry and head of the Laboratory of Membrane Biology and Biophysics at the

Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

and a

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...

investigator. Her research focuses on elucidating the structure and function of ATP-binding cassette (ABC) transporters.

Early life and education

Chen was born in

Changsha Changsha (; ; ; Changshanese pronunciation: (), Standard Mandarin pronunciation: ) is the capital and the largest city of Hunan Province of China. Changsha is the 17th most populous city in China with a population of over 10 million, an ...

, China and graduated from Changsha No. 1 High School in 1988. She studied at

Tongji University Tongji University () is a comprehensive public research university located in Shanghai. Established in 1907 by the German government together with German physicians in Shanghai, Tongji is one of the longest-standing, most selective, and most pr ...

Shanghai Shanghai (; , , Standard Mandarin pronunciation: ) is one of the four direct-administered municipalities of the People's Republic of China (PRC). The city is located on the southern estuary of the Yangtze River, with the Huangpu River flow ...

before moving to the United States. She earned a bachelor's degree in

chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...

from

Ohio University Ohio University is a Public university, public research university in Athens, Ohio. The first university chartered by an Act of Congress and the first to be chartered in Ohio, the university was chartered in 1787 by the Congress of the Confeder ...

in 1993, and went on to pursue PhD in

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

from

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...

in 1998 under the mentorship of

Don C. Wiley Don, don or DON and variants may refer to: Places *County Donegal, Ireland, Chapman code DON *Don (river), a river in European Russia *Don River (disambiguation), several other rivers with the name *Don, Benin, a town in Benin *Don, Dang, a vill ...

, where she discovered unique structural features of the

influenza virus ''Orthomyxoviridae'' (from Greek ὀρθός, ''orthós'' 'straight' + μύξα, ''mýxa'' 'mucus') is a family of negative-sense RNA viruses. It includes seven genera: ''Alphainfluenzavirus'', ''Betainfluenzavirus'', '' Gammainfluenzavirus'', ...

responsible for infection

Career and research

Chen remained in

's lab as a postdoctoral researcher before moving on to a postdoctoral fellowship at

Baylor College of Medicine Baylor College of Medicine (BCM) is a medical school and research center in Houston, Texas, within the Texas Medical Center, the world's largest medical center. BCM is composed of four academic components: the School of Medicine, the Graduate Sc ...

from 1999 to 2001 in the lab o
Florante A. Quiocho
where she started studying the ATP binding cassette transporters In 2002, Chen became an assistant professor at

Purdue University Purdue University is a public land-grant research university in West Lafayette, Indiana, and the flagship campus of the Purdue University system. The university was founded in 1869 after Lafayette businessman John Purdue donated land and money ...

where she won a number of teaching awards and published her research in high impact journals. In 2007, Chen was promoted to associate professor and subsequently, professor in 2011. In 2003 she was named a Pew Scholar and a

Investigator in 2008 In 2014, she moved to The

, where she is now the William E. Ford Professor and Head of Laboratory of Membrane Biology and Biophysics. Her work on

ABC transporters The ATP synthase, ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene family, gene families. It is represented in all extant taxon, extant Phylum ...

includes investigating their role in resistance to

chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherap ...

drugs;

antigen presentation Antigen presentation is a vital immune process that is essential for T cell immune response triggering. Because T cells recognize only fragmented antigens displayed on cell surfaces, antigen processing must occur before the antigen fragment, now ...

adaptive immunity The adaptive immune system, also known as the acquired immune system, is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system ...

and

viral infection A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus particles (virions) attach to and enter susceptible cells. Structural Characteristics Basic structural characteristics, s ...

;

cystic fibrosis Cystic fibrosis (CF) is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. O ...

; and bacterial nutrition. In 2019, she was elected to the National Academy of Sciences.

Awards and honors

* Pew Scholar (2003) * Anatrace Membrane Protein Award, Biophysical Society (2018) * US

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

(2019)

References

{{DEFAULTSORT:Chen, Jue Rockefeller University faculty Ohio University alumni Howard Hughes Medical Investigators Purdue University faculty American women biochemists Harvard University alumni 21st-century American biologists 21st-century American women scientists Year of birth missing (living people) Living people Chemists from Hunan People from Changsha Chinese biochemists Chinese women chemists Chinese emigrants to the United States Tongji University alumni Educators from Hunan Biologists from Hunan