Juda Hirsch Quastel, (October 2, 1899 – October 15, 1987) was a British-Canadian biochemist who pioneered diverse research in
neurochemistry
Neurochemistry is the study of chemicals, including neurotransmitters and other molecules such as psychopharmaceuticals and neuropeptides, that control and influence the physiology of the nervous system. This particular field within neuroscience e ...
, soil metabolism,
cellular metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cell ...
, and
cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
.
Biography
Quastel, also known as "Harry" or "Q," was born at
Ecclesall Road
Ecclesall Road is a road in Sheffield, South Yorkshire, England, that runs for about south-west from Sheffield's city centre under the number A625. At Banner Cross, where the house numbers reach 1001, the road name changes to Ecclesall Road ...
in
Sheffield
Sheffield is a city status in the United Kingdom, city in South Yorkshire, England, whose name derives from the River Sheaf which runs through it. The city serves as the administrative centre of the City of Sheffield. It is Historic counties o ...
the son of Jonas Quastel, a confectioner, and his wife, Flora Itcovitz.
His parents had come to Britain in 1897 from
Tarnopol
Ternópil ( uk, Тернопіль, Ternopil' ; pl, Tarnopol; yi, טאַרנאָפּל, Tarnopl, or ; he, טארנופול (טַרְנוֹפּוֹל), Tarnopol; german: Tarnopol) is a city in the west of Ukraine. Administratively, Ternopi ...
in
Galicia (Eastern Europe) and were married in Britain. He was named after his grandfather,
Juda Quastel, a chemist in Tarnapol.
He was educated at
Sheffield
Sheffield is a city status in the United Kingdom, city in South Yorkshire, England, whose name derives from the River Sheaf which runs through it. The city serves as the administrative centre of the City of Sheffield. It is Historic counties o ...
Central Secondary School. In the
First World War
World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...
he served with the British Army as a Laboratory Assistant at
St George's Hospital
St George's Hospital is a large teaching hospital in Tooting, London. Founded in 1733, it is one of the UK's largest teaching hospitals and one of the largest hospitals in Europe. It is run by the St George's University Hospitals NHS Foundatio ...
from 1917 to 1919.
Electing to study chemistry, Quastel received a baccalaureate from
Imperial College London
Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cu ...
in 1921. Pursuing graduate work at the
University of Cambridge
, mottoeng = Literal: From here, light and sacred draughts.
Non literal: From this place, we gain enlightenment and precious knowledge.
, established =
, other_name = The Chancellor, Masters and Schola ...
, Quastel studied with
Frederick Gowland Hopkins
Sir Frederick Gowland Hopkins (20 June 1861 – 16 May 1947) was an English biochemist who was awarded the Nobel Prize in Physiology or Medicine in 1929, with Christiaan Eijkman, for the discovery of vitamins, even though Casimir Funk, a Po ...
, the leading figure in British biochemistry and a future
Nobel Prize
The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...
recipient for his work on the nutritional importance of
vitamin
A vitamin is an organic molecule (or a set of molecules closely related chemically, i.e. vitamers) that is an Nutrient#Essential nutrients, essential micronutrient that an organism needs in small quantities for the proper functioning of its ...
s. Under Hopkins, Quastel received a
Doctor of Philosophy
A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common Academic degree, degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields ...
degree from the University of Cambridge in
biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
in 1924 and, not long after, was made a Fellow of
Trinity College, Cambridge
Trinity College is a constituent college of the University of Cambridge. Founded in 1546 by Henry VIII, King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any college at either Cambridge ...
.
Quastel remained in Hopkins’ department as a demonstrator and lecturer from 1923 to 1929, during which he pioneered the research of microbial enzymology. He obtained a doctorate of science from Cambridge in 1926 and received a Beit Memorial Fellowship in 1928.
Quastel accepted a position as Director of Research at the
Cardiff
Cardiff (; cy, Caerdydd ) is the capital and largest city of Wales. It forms a principal area, officially known as the City and County of Cardiff ( cy, Dinas a Sir Caerdydd, links=no), and the city is the eleventh-largest in the United Kingd ...
City Mental Hospital in 1930. From this location, he was able to conduct early work on the enzymology and metabolism of the brain. For these studies, Quastel was made a Fellow of the
Royal Society of London
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
in 1940.
In 1941, when Britain's wartime food supply emerged as a strategic concern, the
Agricultural Research Council (ARC) asked Quastel to lead a new research unit focused on improving crop yield at the
Rothamsted Experimental Station
Rothamsted Research, previously known as the Rothamsted Experimental Station and then the Institute of Arable Crops Research, is one of the oldest agricultural research institutions in the world, having been founded in 1843. It is located at Harp ...
. By analyzing soil as a dynamic system, rather than an inert substance, he was able to apply techniques such as
perfusion
Perfusion is the passage of fluid through the circulatory system or lymphatic system to an organ or a tissue, usually referring to the delivery of blood to a capillary bed in tissue. Perfusion is measured as the rate at which blood is deliver ...
, with which he had become familiar in studies of animal organs. On this approach, Quastel later wrote (1946) that "soil as a whole can be considered an organ comparable in some respects to a liver or a gland to which may be added various nutrients, pure or complex degraded plant materials, rain, air, and in which enzymatic reactions can occur."
Using these techniques, Quastel was able to quantify the influence of various plant hormones, inhibitors and other chemicals on the activity of microorganisms in the soil and assess their direct impact on plant growth. While the full work of the unit remained secret, certain discoveries were developed for commercial use after the war. Best known is the compound commonly labeled as
2,4-D, one of the first systemic or hormone
herbicides
Herbicides (, ), also commonly known as weedkillers, are substances used to control undesired plants, also known as weeds.EPA. February 201Pesticides Industry. Sales and Usage 2006 and 2007: Market Estimates. Summary in press releasMain page fo ...
, a class of chemicals responsible for triggering a worldwide revolution in agricultural output and still the most widely used weed-killer in the world. Another invention was developed as a soil conditioner and is marketed by
Monsanto Company
The Monsanto Company () was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri. Monsanto's best known product is Roundup (herbicide), Roundup, a glyphosate-based herbic ...
under the trade name ''Krilium''.
After
World War II
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...
, Quastel was invited to become Assistant Director of the newly founded
McGill University
McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec, Canada. Founded in 1821 by royal charter granted by King George IV,Frost, Stanley Brice. ''McGill Universit ...
-Montreal General Hospital Research Institute and professor of biochemistry at
McGill University
McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec, Canada. Founded in 1821 by royal charter granted by King George IV,Frost, Stanley Brice. ''McGill Universit ...
, and, in 1947, he accepted the invitation. The following year, he was appointed Director of the Institute.
During his nineteen years at
McGill University
McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec, Canada. Founded in 1821 by royal charter granted by King George IV,Frost, Stanley Brice. ''McGill Universit ...
, Quastel supervised seventy Ph.D. candidates and his Institute published over three hundred scientific papers on topics including metabolism of micro-organisms, soil biochemistry, neurobiochemistry, neurotropic drugs, anaesthesia, cancer biochemistry, enzyme inhibition, and transport of nutrients and ions across membranes. Once he reached McGill's retirement age in 1966, Quastel accepted a professorship of neurochemistry at the
University of British Columbia
The University of British Columbia (UBC) is a public university, public research university with campuses near Vancouver and in Kelowna, British Columbia. Established in 1908, it is British Columbia's oldest university. The university ranks a ...
in the Department of Psychiatry, the first such position for that institution.
Quastel received many honors, including, in 1970, Canada's highest recognition, the Companionship of the
Order of Canada
The Order of Canada (french: Ordre du Canada; abbreviated as OC) is a Canadian state order and the second-highest honour for merit in the system of orders, decorations, and medals of Canada, after the Order of Merit.
To coincide with the ...
. In the same year, he received an honorary doctorate from the
Hebrew University
The Hebrew University of Jerusalem (HUJI; he, הַאוּנִיבֶרְסִיטָה הַעִבְרִית בִּירוּשָׁלַיִם) is a public research university based in Jerusalem, Israel. Co-founded by Albert Einstein and Dr. Chaim Weiz ...
in Jerusalem, of which he had also been a governor since 1950. He received an honorary Doctorate of Science from
McGill University
McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec, Canada. Founded in 1821 by royal charter granted by King George IV,Frost, Stanley Brice. ''McGill Universit ...
in 1969. He was made an honorary Fellow of the
Royal Society of Edinburgh
The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established i ...
in 1983.
He died in
Vancouver
Vancouver ( ) is a major city in western Canada, located in the Lower Mainland region of British Columbia. As the List of cities in British Columbia, most populous city in the province, the 2021 Canadian census recorded 662,248 people in the ...
on 16 October 1987.
Family
In 1931 Quastel married Henrietta Jungmann and they had three children—Michael, David and Barbara. Following her death in 1973 he married again in 1975 to Susan Ricardo.
He had eleven grandchildren including mathematician
Jeremy Quastel
Jeremy Daniel Quastel , is a Canadian mathematician specializing in probability theory, stochastic processes, partial differential equations. He is currently head of the mathematics department at the University of Toronto. He grew up in Vancouve ...
.
Publications
*''Chemistry of the Brain'' (1937)
*''The Mechanism of Enzyme Action'' (1940)
*''The Influence of Biochemistry in Modern Life'' (1956)
*''The Chemistry of Brain Metabolism in Health and Disease'' (1961)
*''Metabolic Inhibitors'' (1973)
References
Further reading
*
*
Royal Society citation
{{DEFAULTSORT:Quastel, Judah Hirsch
1899 births
1987 deaths
Alumni of Imperial College London
Alumni of Trinity College, Cambridge
British expatriates in Canada
Canadian biochemists
English biochemists
English biologists
Fellows of the Royal Society
Fellows of the Royal Society of Edinburgh
Companions of the Order of Canada
McGill University faculty
Neurochemists
People from Sheffield
Pesticides in the United Kingdom
Rothamsted Experimental Station people
British Jews
Jewish scientists
Scientists from Vancouver
Scientists from Montreal
20th-century English scientists
Scientists from Yorkshire
20th-century Canadian biologists
Canadian Fellows of the Royal Society