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Joshua Harold Burn FRS (6 March 1892 – 13 July 1981) was an English
pharmacologist Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
and professor of pharmacology at
Oxford University Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the ...
. Burn worked on the internal control of the body by the autonomic nervous system, carrying out seminal work on the release of noradrenaline from these nerves and introducing the controversial Burn-Rand hypothesis. The
Nobel Laureate The Nobel Prizes ( sv, Nobelpriset, no, Nobelprisen) are awarded annually by the Royal Swedish Academy of Sciences, the Swedish Academy, the Karolinska Institutet, and the Norwegian Nobel Committee to individuals and organizations who make out ...
John Vane Sir John Robert Vane (29 March 1927 – 19 November 2004) was a British pharmacologist who was instrumental in the understanding of how aspirin produces pain-relief and anti-inflammatory effects and his work led to new treatments for heart and ...
claimed "If anyone can be said to have moulded the subject of pharmacology around the world, it is he".


Life

Burn was born in
Barnard Castle Barnard Castle (, ) is a market town on the north bank of the River Tees, in County Durham, Northern England. The town is named after and built around a medieval castle ruin. The town's Bowes Museum's has an 18th-century Silver Swan automato ...
, County Durham, England.Joshua Harold Burn. 6 March 1892 – 13 July 1981 Edith Bülbring and J. M. Walker Page 47 of 44–89 He was educated at
Barnard Castle School Barnard Castle School (colloquially Barney School or locally the County School) is a co-educational Independent school (United Kingdom), independent day and boarding school in the market town of Barnard Castle, County Durham, in the North East Engl ...
. Burn entered
Emmanuel College, Cambridge Emmanuel College is a constituent college of the University of Cambridge. The college was founded in 1584 by Sir Walter Mildmay, Chancellor of the Exchequer to Elizabeth I. The site on which the college sits was once a priory for Dominican mon ...
in 1909 where he read the
Natural Sciences Natural science is one of the branches of science concerned with the description, understanding and prediction of natural phenomena, based on empirical evidence from observation and experimentation. Mechanisms such as peer review and repeatab ...
Tripos At the University of Cambridge, a Tripos (, plural 'Triposes') is any of the examinations that qualify an undergraduate for a bachelor's degree or the courses taken by a student to prepare for these. For example, an undergraduate studying mathe ...
. He specialised in
physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...
for Part II. His tutor was
Frederick Gowland Hopkins Sir Frederick Gowland Hopkins (20 June 1861 – 16 May 1947) was an English biochemist who was awarded the Nobel Prize in Physiology or Medicine in 1929, with Christiaan Eijkman, for the discovery of vitamins, even though Casimir Funk, a Po ...
. After receiving his BA he was awarded a research grant by Emmanuel College and a Michael Foster Studentship by the university. The next 18 months were spent in research with
Joseph Barcroft Sir Joseph Barcroft (26 July 1872 – 21 March 1947) was a British physiologist best known for his studies of the oxygenation of blood. Life Born in Newry, County Down into a Quaker family, he was the son of Henry Barcroft DL and Anna Richar ...
. Other figures in physiology at Cambridge at the time were Keith Lucas and the
Nobel Laureates The Nobel Prizes ( sv, Nobelpriset, no, Nobelprisen) are awarded annually by the Royal Swedish Academy of Sciences, the Swedish Academy, the Karolinska Institutet, and the Norwegian Nobel Committee to individuals and organizations who make ou ...
Archibald Hill Archibald Vivian Hill (26 September 1886 – 3 June 1977), known as A. V. Hill, was a British physiologist, one of the founders of the diverse disciplines of biophysics and operations research. He shared the 1922 Nobel Prize in Physiology or M ...
and
Edgar Adrian Edgar Douglas Adrian, 1st Baron Adrian (30 November 1889 – 4 August 1977) was an English electrophysiologist and recipient of the 1932 Nobel Prize for Physiology, won jointly with Sir Charles Sherrington for work on the function of neurons. ...
. In January 1914 Burn went to work for
Henry Hallett Dale Sir Henry Hallett Dale (9 June 1875 – 23 July 1968) was an English pharmacologist and physiologist. For his study of acetylcholine as agent in the chemical transmission of nerve pulses (neurotransmission) he shared the 1936 Nobel Prize in Ph ...
in London. In October 1914, Burn enlisted in the army as a Signals Officer with the rank of corporal. By the end of 1917 he was required to return to England to finish his medical training. From 1920 to 1926 he worked with Henry Dale at the
National Institute for Medical Research The National Institute for Medical Research (commonly abbreviated to NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC); In 2016, the NIMR b ...
in
Hampstead Hampstead () is an area in London, which lies northwest of Charing Cross, and extends from Watling Street, the A5 road (Roman Watling Street) to Hampstead Heath, a large, hilly expanse of parkland. The area forms the northwest part of the Lon ...
. His work involved the standardisation of medicines. In 1926 he became director of the Pharmacological Laboratories at the
Pharmaceutical Society of Great Britain The Royal Pharmaceutical Society of Great Britain (RPSGB) existed from its founding as the Pharmaceutical Society of Great Britain in 1841 until 2010. The word "Royal" was added to its name in 1988. It was the statutory regulatory and professional ...
, again involved in the standardisation of medicines. Between 1926 and 1937 Burn had 44 co-workers, of which 30 came from overseas.Joshua Harold Burn. 6 March 1892 – 13 July 1981 Edith Bülbring and J. M. Walker Page 52 of 44–89 From 1933 he worked closely with Edith Bülbring. In 1931 he was a founder member of the
British Pharmacological Society The British Pharmacological Society is the primary UK learned society for pharmacologists concerned with research into drugs and the way they work. Members work in academia, industry, regulatory agencies and the health services, and many are medi ...
and he was a member of the commission that produced the reforming
British Pharmacopoeia The ''British Pharmacopoeia'' (''BP'') is the national pharmacopoeia of the United Kingdom. It is an annually published collection of quality standards for medicinal substances in the UK, which is used by individuals and organisations involve ...
in 1932. In 1933 he was appointed Dean of
The School of Pharmacy, University of London The UCL School of Pharmacy (formerly The School of Pharmacy, University of London) is the pharmacy school of University College London (UCL). The School forms part of UCL's UCL Faculty of Life Sciences, Faculty of Life Sciences and is located in ...
. From 1937 to 1959 Burn held the chair of Pharmacology at the
University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...
.Joshua Harold Burn. 6 March 1892 – 13 July 1981 Edith Bülbring and J. M. Walker Page 53 of 44–89 Over the years he had 162 academic staff, including
John Robert Vane Sir John Robert Vane (29 March 1927 – 19 November 2004) was a British pharmacologist who was instrumental in the understanding of how aspirin produces pain-relief and anti-inflammatory effects and his work led to new treatments for heart and b ...
(1927–2004), one of three winners of the Nobel Prize in Physiology or Medicine in 1982. Burn was an honorary Doctor of
Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the wo ...
, the
University of Mainz The Johannes Gutenberg University Mainz (german: Johannes Gutenberg-Universität Mainz) is a public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946. With approximately 32,000 stu ...
and the
University of Bradford The University of Bradford is a Public university, public research university located in the city of Bradford, West Yorkshire, England. A plate glass university, it received its royal charter in 1966, making it the 40th university to be creat ...
. He was an honorary member of the
British Pharmacological Society The British Pharmacological Society is the primary UK learned society for pharmacologists concerned with research into drugs and the way they work. Members work in academia, industry, regulatory agencies and the health services, and many are medi ...
, the German Pharmacological Society and the Czechoslovakian Medical Society of
Jan Evangelista Purkyně Jan Evangelista Purkyně (; also written Johann Evangelist Purkinje) (17 or 18 December 1787 – 28 July 1869) was a Czech anatomist and physiologist. In 1839, he coined the term '' protoplasm'' for the fluid substance of a cell. He was one of t ...
and a member of the
Leopoldina Leopoldina may refer to: * Colônia Leopoldina, a Brazilian municipality in the state of Alagoa * Leopoldina, Minas Gerais, a Brazilian municipality in the state of Minas Gerais * Maria Leopoldina of Austria (1797-1826), consort of emperor Pedro I ...
and a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
(elected 1942) . In 1967 he received the Schmiedeberg-badge of the German Pharmacological Society and in 1979 the Wellcome Gold Medal of the British Pharmacological Society.


Publications

Methods of Biological Assay, 1928; Recent Advances in Materia Medica, 1931; Biological Standardization, 1937; Background of Therapeutics, 1948; Lecture Notes on Pharmacology, 1948; Practical Pharmacology, 1952; Functions of Autonomic Transmitters, 1956; The Principles of Therapeutics, 1957; Drugs, Medicines and Man, 1962; The Autonomic Nervous System, 1963; Our most interesting Diseases, 1964; A Defence of John Balliol, 1970


References


External links





{{DEFAULTSORT:Burn, Joshua Harold 1892 births 1981 deaths People from Barnard Castle People educated at Barnard Castle School English pharmacologists Fellows of the Royal Society Alumni of Emmanuel College, Cambridge British Army personnel of World War I National Institute for Medical Research faculty