Josef, Baron von Mering (28 February 1849, in
Cologne
Cologne ( ; german: Köln ; ksh, Kölle ) is the largest city of the German western state of North Rhine-Westphalia (NRW) and the fourth-most populous city of Germany with 1.1 million inhabitants in the city proper and 3.6 millio ...
– 5 January 1908, at
Halle an der Saale
Halle (Saale), or simply Halle (; from the 15th to the 17th century: ''Hall in Sachsen''; until the beginning of the 20th century: ''Halle an der Saale'' ; from 1965 to 1995: ''Halle/Saale'') is the largest city of the German state of Saxony-Anh ...
,
Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
) was a German physician.
Working at the
University of Strasbourg
The University of Strasbourg (french: Université de Strasbourg, Unistra) is a public research university located in Strasbourg, Alsace, France, with over 52,000 students and 3,300 researchers.
The French university traces its history to the ea ...
, Mering was the first person to discover (in conjunction with
Oskar Minkowski
Oskar Minkowski (; 13 January 1858 – 18 July 1931) was a German physician and physiologist who held a professorship at the University of Breslau and is most famous for his research on diabetes. He was the brother of the mathematician Hermann M ...
) that one of the pancreatic functions is the production of
insulin, a
hormone
A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are require ...
which controls blood sugar levels.
Mering was curious about the
pancreas
The pancreas is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine gland, i.e. it has both an en ...
, a
comma shaped organ, situated between the
stomach
The stomach is a muscular, hollow organ in the gastrointestinal tract of humans and many other animals, including several invertebrates. The stomach has a dilated structure and functions as a vital organ in the digestive system. The stomach i ...
and the
small intestine. In an effort to discover its function, he removed the organ from a dog. The dog was then noticed frequently urinating on the floor, although it was house trained. Mering realised that this was a symptom of
diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...
and tested the
urine
Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excreted from the body through the urethra.
Cellular ...
, which was found to be high in sugar, confirming his suspicion.
Josef von Mering helped to discover
barbiturates, a class of sedative drugs used for insomnia, epilepsy, anxiety, and anesthesia. In 1903, he published observations that
barbital
Barbital (or barbitone), marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemic ...
(then known as diethyl-barbituric acid) has sedative properties in humans. In 1904, he helped to launch barbital under the brand name Veronal. Veronal was the first commercially available barbiturate sedative in any country. Von Mering collaborated with the chemist
Emil Fischer
Hermann Emil Louis Fischer (; 9 October 1852 – 15 July 1919) was a German chemist and 1902 recipient of the Nobel Prize in Chemistry. He discovered the Fischer esterification. He also developed the Fischer projection, a symbolic way of draw ...
, who was also involved in the discovery of barbital.
References
Joseph von Meringat
Encyclopædia Britannica
The (Latin for "British Encyclopædia") is a general knowledge English-language encyclopaedia. It is published by Encyclopædia Britannica, Inc.; the company has existed since the 18th century, although it has changed ownership various t ...
1849 births
1908 deaths
19th-century German physicians
Physicians from Cologne
People from the Rhine Province
University of Bonn alumni
University of Greifswald alumni
University of Strasbourg alumni
University of Strasbourg faculty
Martin Luther University of Halle-Wittenberg faculty
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