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Sir Joseph Arthur Arkwright MA MD MRCS FRCP FRS (22 March 1864 – 22 November 1944) was a medical doctor. He was forced to give up his work due to severe
dermatitis Dermatitis is inflammation of the skin, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened. The area of skin involved can ...
. He became a
bacteriologist A bacteriologist is a microbiologist, or similarly trained professional, in bacteriology -- a subdivision of microbiology that studies bacteria, typically pathogenic ones. Bacteriologists are interested in studying and learning about bacteria, ...
and from 1906 joined the
Lister Institute of Preventive Medicine The Lister Institute of Preventive Medicine, informally known as the Lister Institute, was established as a research institute (the British Institute of Preventive Medicine) in 1891, with bacteriologist Marc Armand Ruffer as its first director, u ...
, first as a voluntary worker, then as assistant bacteriologist from 1908. W J Bishop, ‘Arkwright, Sir Joseph Arthur (1864–1944)’ revd Claire E J Herrick, Oxford Dictionary of National Biography, Oxford University Press, 2004, accessed 6 June 2015
/ref>Royal College of Physicians, accessed 6 June 2015
/ref>Wiley online Library Published 10 June 2005, Accessed 7 June 2015
/ref>


Early life and education

He was born at Thurlaston, Leicestershire, England, the youngest of the five children of Arthur William Arkwright, a farmer, of Broughton Hall, Astley, Leicestershire and his wife and second cousin, Emma, daughter of John Wolley, of Beeston,
Nottinghamshire Nottinghamshire (; abbreviated Notts.) is a landlocked county in the East Midlands region of England, bordering South Yorkshire to the north-west, Lincolnshire to the east, Leicestershire to the south, and Derbyshire to the west. The trad ...
. His mother died in 1866. His great-great-grandfather was Sir Richard Arkwright the inventor of textile manufacturing machinery. He was educated at
Wellington College Wellington College may refer to: *Wellington College, Berkshire, an independent school in Crowthorne, Berkshire, England ** Wellington College International Shanghai ** Wellington College International Tianjin * Wellington College, Wellington, Ne ...
and
Trinity College, Cambridge Trinity College is a constituent college of the University of Cambridge. Founded in 1546 by King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any college at either Cambridge or Oxford. ...
. At Cambridge he took the natural sciences tripos in 1884–6 with zoology his major subject. He completed his medical training at
St Bartholomew's Hospital St Bartholomew's Hospital, commonly known as Barts, is a teaching hospital located in the City of London. It was founded in 1123 and is currently run by Barts Health NHS Trust. History Early history Barts was founded in 1123 by Rahere (die ...
(Barts), London, qualifying in 1889.


Career

He held posts at Barts and later at the West London Hospital in Hammersmith and the Victoria Hospital for Children, in Fulham. Later he settled in general practice at
Halesowen Halesowen ( ) is a market town in the Metropolitan Borough of Dudley, in the county of West Midlands, England. Historically an exclave of Shropshire and, from 1844, in Worcestershire, the town is around from Birmingham city centre, and fro ...
, then in
Worcestershire Worcestershire ( , ; written abbreviation: Worcs) is a county in the West Midlands of England. The area that is now Worcestershire was absorbed into the unified Kingdom of England in 927, at which time it was constituted as a county (see H ...
, now part of the
West Midlands West or Occident is one of the four cardinal directions or points of the compass. It is the opposite direction from east and is the direction in which the Sun sets on the Earth. Etymology The word "west" is a Germanic word passed into some ...
. However, after he suffered severe
dermatitis Dermatitis is inflammation of the skin, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened. The area of skin involved can ...
and was forced to give up general practice. In 1906 he joined the Lister Institute of Preventive Medicine, first as a voluntary worker, then as assistant bacteriologist from 1908. His early work considered the spread of
diphtheria Diphtheria is an infection caused by the bacterium '' Corynebacterium diphtheriae''. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks more than 10% of those diagnosed with the disease may die. Signs and s ...
in schools and the differentiation of
meningococcus ''Neisseria meningitidis'', often referred to as meningococcus, is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening sepsis. The bacterium is referred to as a ...
strains. In 1915 he studied an epidemic of
cerebrospinal meningitis Meningitis is acute or chronic inflammation of the protective membranes covering the brain and spinal cord, collectively called the meninges. The most common symptoms are fever, headache, and neck stiffness. Other symptoms include confusion or a ...
among troops camped on Salisbury Plain. In 1915 during the
First World War World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...
he joined the Royal Army Medical Corps and was posted to
Malta Malta ( , , ), officially the Republic of Malta ( mt, Repubblika ta' Malta ), is an island country in the Mediterranean Sea. It consists of an archipelago, between Italy and Libya, and is often considered a part of Southern Europe. It lies ...
. There he was
pathologist Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in t ...
in charge of the laboratory at St George's Hospital. He made observations on convalescent carriers in bacillary
dysentery Dysentery (UK pronunciation: , US: ), historically known as the bloody flux, is a type of gastroenteritis that results in bloody diarrhea. Other symptoms may include fever, abdominal pain, and a feeling of incomplete defecation. Complications ...
and also blackwater fever. In 1918 he was appointed a member of the War Office committee on
trench fever Trench fever (also known as "five-day fever", "quintan fever" ( la, febris quintana), and "urban trench fever") is a moderately serious disease transmitted by body lice. It infected armies in Flanders, France, Poland, Galicia, Italy, Salonika, Ma ...
. Together with Arthur Bacot and F. Martin Duncan he demonstrated the association of the trench fever virus with Rickettsia quintana in lice. His most important work was bacterial variation. He noted variants as R and S (rough and smooth) in bacilli of the dysentery and enteric group. In 1922 he went with Bacot to
Cairo Cairo ( ; ar, القاهرة, al-Qāhirah, ) is the Capital city, capital of Egypt and its largest city, home to 10 million people. It is also part of the List of urban agglomerations in Africa, largest urban agglomeration in Africa, List of ...
to investigate the cause of typhus fever. After two months' work they both contracted the disease. Bacot died, and Arkwright recovered after a long illness. On return to the Lister, he investigated animal diseases including
foot-and-mouth Foot-and-mouth disease (FMD) or hoof-and-mouth disease (HMD) is an infectious and sometimes fatal viral disease that affects cloven-hoofed animals, including domestic and wild bovids. The virus causes a high fever lasting two to six days, follow ...
. From 1925 onwards he was a member of the Ministry of Agriculture's committee on the disease. He became its chairman in 1931. He was a member of the Medical Research Council from 1930 to 1934 and the
Agricultural Research Council The Agricultural and Food Research Council (AFRC) was a British Research Council responsible for funding and managing scientific and technological developments in farming and horticulture. History The AFRC was formed in 1983 from its predecessor ...
from 1931 to 1940. He was chairman of the committee on
Brucella abortus ''Brucella abortus'' is a Gram-negative bacterium in the family Brucellaceae and is one of the causative agents of brucellosis. The rod-shaped pathogen is classified under the domain Bacteria. The prokaryotic ''B. abortus'' is non-spore-forming, ...
infection and on
Johne's disease Paratuberculosis is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants. It is caused by the bacterium ''Mycobacterium avium'' subspecies ''paratuberculosis''. Infections normally affect ru ...
(
Paratuberculosis Paratuberculosis is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants. It is caused by the bacterium ''Mycobacterium avium'' subspecies ''paratuberculosis''. Infections normally affect ru ...
). He also chaired the joint committee on
tuberculosis Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, i ...
. He retired from the Lister in 1927 but continued to work as an honorary member and represented the Royal Society on the Lister governing body from 1932 to 1944. He had produced over fifty papers on bacteriology and immunology.


Honours

He was appointed FRCP in 1916, FRS in 1926, and was knighted in 1937.The London Gazette Publication date: 29 January 1937 Supplement:34365 Page:688, accessed 9 June 2015 He died in
King's College Hospital King's College Hospital is a major teaching hospital and major trauma centre in Denmark Hill, Camberwell in the London Borough of Lambeth, referred to locally and by staff simply as "King's" or abbreviated internally to "KCH". It is managed b ...
, south London.


Personal life

In 1893, he married Ruth (d. 1950), daughter of Joseph William Wilson, a civil engineer. They had three daughters, two of whom became doctors.


Publications

''The Carrier Problem in Infectious Diseases'' Authors:
John Charles Grant Ledingham Sir John Charles Grant Ledingham Fellow of the Royal Society, FRS (19 May 1875 – 4 October 1944) was a British pathologist and bacteriologist. Ledinham was born at Boyndie (Banffshire, Banff) where James Ledingham, his father, was the local ch ...
FRS and Joseph Arkwright: Original publication c.1923


References

{{DEFAULTSORT:Arkwright, Joseph Arthur 1864 births 1944 deaths 19th-century British biologists 20th-century British biologists British pathologists British bacteriologists Fellows of the Royal Society