Josef Kyrle (8 December 1880 – 30 March 1926) was an Austrian

pathologist Pathology is the study of the causal, causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when us ...

and

dermatologist Dermatology is the branch of medicine dealing with the skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medical ...

who was a native of

Schärding Schärding ( , Bavarian name: Scharing) is a town in northern Austrian state of Upper Austria, the capital of the district of the same name, and a major port on the Inn River. Historically, it was owned by the Wittelsbach family, which reflects ...

. He studied medicine at the

University of Graz The University of Graz (german: link=no, Karl-Franzens-Universität Graz, ), located in Graz, Austria, is the largest and oldest university in Styria, as well as the second-largest and second-oldest university in Austria. History The unive ...

, and afterwards was an assistant to Anton Weichselbaum (1845–1920) at the clinic of

pathological anatomy Anatomical pathology (''Commonwealth'') or Anatomic pathology (''U.S.'') is a medical specialty that is concerned with the diagnosis of disease based on the macroscopic, microscopic, biochemical, immunologic and molecular examination ...

at the

University of Vienna The University of Vienna (german: Universität Wien) is a public research university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world. With its long and rich histor ...

. In 1907 he was an assistant to Ernst Finger (1856–1939) at the dermatology clinic in

Vienna en, Viennese , iso_code = AT-9 , registration_plate = W , postal_code_type = Postal code , postal_code = , timezone = CET , utc_offset = +1 , timezone_DST ...

, and in 1918 he became an associate professor. Kyrle specialized in microscopic and

histological Histology, also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures vis ...

research of skin disorders. His name is associated with

Kyrle disease Kyrle disease is identified as a form of an acquired perforating disease. Other major perforating diseases are elastosis perforans serpiginosa and reactive perforating collagenosis. Recently, however, there is a controversy on categorizing Kyrle d ...

, being also known as "

hyperkeratosis Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis, or skin), often associated with the presence of an abnormal quantity of keratin,Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) ''Robbins & Cotran Patholo ...

penetrans". In 1916 Kyrle referred to this condition as ''hyperkeratosis follicularis et parafollicularis in cutem penetrans''. It is characterized by keratotic plugs that develop in

hair follicle The hair follicle is an organ found in mammalian skin. It resides in the dermal layer of the skin and is made up of 20 different cell types, each with distinct functions. The hair follicle regulates hair growth via a complex interaction between h ...

s and eccrine ducts, penetrating the

epidermis The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and hypodermis. The epidermis layer provides a barrier to infection from environmental pathogens and regulates the amount of water rele ...

and extending into the

dermis The dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain. It is divided i ...

. This disorder is often associated with

diabetes mellitus Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

and

kidney failure Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as eit ...

. He performed investigations on the use of Jauregg's

malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. S ...

therapy for treatment of

syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, an ...

in its early stages, and with Dr. Weichselbaum, he performed important studies involving the origin and development of the

islets of Langerhans The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans. The pancreatic islets constitute 1–2% of ...

in the fetus.

Selected writings

* ''Über den derzeitigen Stand der Lehre von der Pathologie und Therapie der Syphilis; sechs Vorlesungen für praktische Ärzte'', 1924 - On the current state involving the doctrine of pathology and therapy of syphilis. * ''Vorlesungen über Histo-Biologie der menschlichen Haut und ihrer Erkrankungen'', 1925-27 - Lectures about histo-biology of

human skin The human skin is the outer covering of the body and is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue guarding muscles, bones, ligaments and internal organs. Human skin is similar to most ...

and its diseases.WorldCat Search
(publications)

References

Kyrle's disease *

(translated from German) * ttp://nobelprize.org/nobel_prizes/medicine/laureates/1927/wagner-jauregg-lecture.htmlThe Treatment of Dementia Paralytica by Malaria Inoculation Austrian dermatologists Austrian pathologists 1880 births 1926 deaths Academic staff of the University of Vienna Dermatologists from Austria-Hungary Pathologists from Austria-Hungary {{austria-med-bio-stub