Jonathan L. Halperin (born January 29, 1949) is an American cardiologist and the author of ''Bypass'' (), among the most comprehensive works on the subject of coronary artery bypass surgery. In addition, he is the Robert and Harriet Heilbrunn Professor of Medicine at The

Mount Sinai School of Medicine The Icahn School of Medicine at Mount Sinai (ISMMS or Mount Sinai), formerly the Mount Sinai School of Medicine, is a private medical school in New York City. It is the academic teaching arm of the Mount Sinai Health System, which manages eigh ...

as well as Director of Clinical Cardiology in the Zena and Michael A. Wierner Cardiovascular Institute at The

Mount Sinai Medical Center Mount Sinai Hospital, formerly at times known as Mount Sinai Medical Center, is a 319-bed major urban hospital in Chicago, Illinois, with its main campus located adjacent to Douglass Park at 15th Street and California Avenue on the city's West Si ...

, both in

New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...

. Halperin was the principal cardiologist responsible for both the design and execution of the multi-center Stroke Prevention in Atrial Fibrillation (SPAF) clinical trials, funded by the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

, which helped develop

antithrombotic An antithrombotic agent is a drug that reduces the formation of blood clots (thrombi).http://cancerweb.ncl.ac.uk/cgi-bin/omd?antithrombotic Antithrombotics can be used therapeutically for prevention (primary prevention, secondary prevention) or tr ...

strategies to prevent

stroke A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functionin ...

, and he subsequently directed the SPORTIF clinical trials, which evaluated the first oral direct thrombin inhibitor for prevention of stroke in patients with atrial fibrillation. Halperin is the author of 3 books, 80 original peer reviewed reports, 38 chapters, 24 guidelines and position statements, 51 invited articles and 58 abstracts. He is listed among

New York Magazine ''New York'' is an American biweekly magazine concerned with life, culture, politics, and style generally, and with a particular emphasis on New York City. Founded by Milton Glaser and Clay Felker in 1968 as a competitor to ''The New Yorker'', ...

’s Best Doctors of 2009.

Biography

Halperin was born in 1949 in

Boston Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- mo ...

Massachusetts Massachusetts (Massachusett language, Massachusett: ''Muhsachuweesut assachusett writing systems, məhswatʃəwiːsət'' English: , ), officially the Commonwealth of Massachusetts, is the most populous U.S. state, state in the New England ...

. He earned his A.B. from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

in 1971 and his M.D. from

Boston University Boston University (BU) is a private research university in Boston, Massachusetts. The university is nonsectarian, but has a historical affiliation with the United Methodist Church. It was founded in 1839 by Methodists with its original campu ...

in 1975. He completed an internship in medicine (in 1976) and a residency in internal medicine (in 1977), both at University Hospital, Boston. He was a clinical and research fellow in peripheral vascular disease at the Evans Memorial Foundation for Clinical Research in Boston (1977–1978) and a fellow in cardiology at Boston City Hospital (1978–1980). He served academic appointments at Boston City Hospital, St. Elizabeth's Hospital in

Brighton, Massachusetts Brighton is a Municipal annexation in the United States, former town and current Neighborhoods in Boston, neighborhood of Boston, Massachusetts, United States, located in the northwestern corner of the city. It is named after the English city of ...

Boston University School of Medicine The Boston University Chobanian & Avedisian School of Medicine, formerly the Boston University School of Medicine, is one of the graduate schools of Boston University. Founded in 1848, the medical school was the first institution in the world ...

and the

American Heart Association The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate cardiac care in an effort to reduce disability and death ...

. In 1980, Halperin was appointed to The Mount Sinai School of Medicine as an Assistant Professor of Medicine. In 1993, he was named the Robert and Harriet Heilbrunn Professor of Medicine. Halperin is a fellow of the American College of Cardiology, the

, and the Councils on Circulation, Stroke and Cardiology of the American Heart Association. He is past president of the Society for Vascular Medicine. Current federal appointments include the U.S Food and Drug Administration’s Cardiovascular and Renal Advisory Committee, and the Data Safety Monitoring Board for the Clinical Trial of

Aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...

and

Simvastatin Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. It is also used to decrease the risk of heart ...

in Pulmonary Arterial Hypertension for the National Institutes of Health. Clinical investigation topics include congestive

heart failure Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome, a group of signs and symptoms caused by an impairment of the heart's blood pumping function. Symptoms typically include shortness of breath, excessive fatigue, a ...

Raynaud's disease Raynaud syndrome, also known as Raynaud's phenomenon, eponymously named after the physician Auguste Gabriel Maurice Raynaud, who first described it in his doctoral thesis in 1862, is a medical condition in which the spasm of small arteries cau ...

and

mitral valve disease Mitral regurgitation (MR), also known as mitral insufficiency or mitral incompetence, is a form of valvular heart disease in which the mitral valve is insufficient and does not close properly when the heart pumps out blood.

Honors and awards

Extramural honors and awards include: *Master of the Society for Vascular Medicine, 2009https://www.vascularmed.org/awards/master.cfm , Society of Vascular Medicine *The Heart of New York Award, 2005 *The Heart of New York Presidential Salute, 2002 *Howard B. Sprague Research Fellowship Award, 1979

Books

*Halperin JL, Levine R: BYPASS: A Cardiologist Reveals What Every Patient Needs To Know. New York: Times Books – Random House, 1985 ; Phoenix: The Body Press – HP Books, 1987 *Gross PA, Halperin JL, Lipkin M, Marks JH, Rivlin RS, Wise TN, Grzelka C: Managing Your Health: Strategies for Lifelong Good Health. Yonkers, NY: Consumer Reports Books, 1991. *Connolly SJ, Gore JL, Halperin JL. Aligning Clinical Practice with Evidence for Prevention of Thromboembolism in Atrial Fibrillation. Institute for Continuing Healthcare Education, 2002.

Publications

Partial list: * * * * * * * * * * * * * * * * *

References

External links

Mount Sinai Hospital homepageIcahn School of Medicine at Mount Sinai homepageTheHeart.org
Kowey PR, Halperin JL, Yusuf S. Trial Design for Anticoagulation in Atrial Fibrillation Patients. American College of Cardiology Annual Scientific Sessions, March 30, 2009

A Mount Sinai cardiologist makes sure your heart's in the right place. By Katie Charles, February 13, 2008 {{DEFAULTSORT:Halperin, Jonathan L. 1949 births American cardiologists Boston University School of Medicine alumni Columbia University alumni Living people Icahn School of Medicine at Mount Sinai faculty Physicians from Boston Fellows of the American College of Cardiology