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John Conrad Waterlow (13 June 1916 – 19 October 2010) was a British
physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical a ...
who specialised in childhood malnutrition. Waterlow was born into a well known London printing family. Whilst growing up, the family home was often visited by the likes of EM Forster and Virginia Woolf.


Education

Waterlow was educated at Eton College. Whilst at school, Warterlow was inspired by a lecture about Leprosy in West Africa given by Tubby Clayton. Consequently, he went on to study natural sciences at Trinity College, Cambridge in 1935, before changing to study medicine and physiology instead. He graduated in 1935 with a first class degree in physiology and went on to qualify as a doctor in 1942 having studied at the
London Hospital Medical College Barts and The London School of Medicine and Dentistry, commonly known as Barts or BL, is a medical school, medical and dental school in London, England. The school is part of Queen Mary University of London, a constituent college of the federal Un ...
, during which much time was spent treating casualties of The Blitz.


Career

After qualifying as a doctor, he was attached to the Medical Research Council's (MRC) military personnel research programme, working under BS Platt, where he spent a year studying heat stroke and heat exhaustion in Basra. After the second world war had ended, Platt became the head of a new research unit at the MRC, focusing on nutrition and Waterlow followed him and worked with the unit. During this time, Platt imprinted the a prediction on Waterlow that, "Nutrition will be the problem of the future". He was sent to the Caribbean in 1945 to investigate why large numbers of children there were dying and discovered that many had oedematous malnutrition and fatty livers, but was unsure why this was the case. To investigate the cases, he made a
microbalance A microbalance is an instrument capable of making precise measurements of weight of objects of relatively small mass: of the order of a million parts of a gram. In comparison, a standard analytical balance is 100 times less sensitive; i.e. it is ...
using the newly invented adhesive Araldite, to weigh 2 mg samples of liver tissue and also a microrespirometer to measure the enzyme activity in the samples. The microrespirometer is said to have been much more sensitive than those used by other biochemists at the time and the microbalance was sensitive to within one millionth of a gram. He subsequently discovered that the syndrome he was observing was the same as
Kwashiorkor Kwashiorkor ( , ) is a form of severe protein malnutrition characterized by edema and an enlarged liver with fatty infiltrates. It is thought to be caused by sufficient calorie intake, but with insufficient protein consumption (or lack of goo ...
which had been described a few years earlier in Africa. Waterlow set about investigating the biochemical basis of Kwashiorkor, both in the West Indies and at several field stations in Africa. He was the founding editor of the ''
European Journal of Clinical Nutrition The ''European Journal of Clinical Nutrition'' is a monthly peer-reviewed medical journal covering nutrition science and published by the Springer Nature. It was established in 1947 by John Waterlow as ''Nutrition'' and renamed ''Journal of Human ...
''. He was elected Fellow of the Royal Society in 1982. Whilst in the Caribbean he established 'The Tropical Metabolism Research Unit' at the
University of the West Indies The University of the West Indies (UWI), originally University College of the West Indies, is a public university system established to serve the higher education needs of the residents of 17 English-speaking countries and territories in th ...
in Jamaica.


Written work

Waterlow wrote extensively during the course of his career, but perhaps his most famous works include: 'Protein turnover in mammalian tissues and in the whole body'- (1978)- JC Waterlow, P.J Garlick and D.J Millward. 'Protein-energy malnutrition: the nature and extent of the problem'- (1992)- JC Waterlow.


Personal life

Waterlow was the son of
Sir Sydney Waterlow Sir Sydney Hedley Waterlow, 1st Baronet, (1 November 1822 – 3 August 1906) was a British philanthropist and Liberal Party politician, principally remembered for donating Waterlow Park to the public as "a garden for the gardenless". Life He w ...
, a British diplomat and Helen Eckhard who was from a well off family of German immigrants living in Manchester. In 1939 he married Angela Grey who was a history student at Cambridge University and they later went on to have two sons and one daughter;
Sarah Sarah (born Sarai) is a biblical matriarch and prophetess, a major figure in Abrahamic religions. While different Abrahamic faiths portray her differently, Judaism, Christianity, and Islam all depict her character similarly, as that of a piou ...
, Oliver and Dick.


References


External links

* {{DEFAULTSORT:Waterlow, John 1916 births 2010 deaths Alumni of Trinity College, Cambridge British physiologists Foreign associates of the National Academy of Sciences