John Newport Langley (2 November 1852 – 5 November 1925) was a British

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical a ...

, who made substantive discoveries about the

nervous system In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body. The nervous system detects environmental changes th ...

and

secretion 440px Secretion is the movement of material from one point to another, such as a secreted chemical substance from a cell or gland. In contrast, excretion is the removal of certain substances or waste products from a cell or organism. The classical ...

Life

He was born in

Newbury, Berkshire Newbury is a market town in the county of Berkshire, England, and is home to the administrative headquarters of West Berkshire Council. The town centre around its large market square retains a rare medieval Cloth Hall, an adjoining half timbere ...

the son of John Langley, the local schoolmaster, and his wife, Mary Groom. He was educated at

Exeter Grammar School Exeter School is an independent co-educational day school for pupils between the ages of 7 and 18 in Exeter, Devon, England. In 2019, there were around 200 pupils in the Junior School and 700 in the Senior School. History The School traces its ...

Devon Devon ( , historically known as Devonshire , ) is a ceremonial and non-metropolitan county in South West England. The most populous settlement in Devon is the city of Plymouth, followed by Devon's county town, the city of Exeter. Devon is ...

. In 1871 he won a place at

St John's College, Cambridge St John's College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge founded by the House of Tudor, Tudor matriarch Lady Margaret Beaufort. In constitutional terms, the college is a charitable corpo ...

, where he graduated MA before continuing multiple postgraduate studies, gaining several doctorates. He spent his entire career at

Cambridge University , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

, beginning as a Demonstrator in lectures in 1875. He began lecturing in Physiology in 1884 and was awarded a professorship in 1903, succeeding Prof Michael Foster. He was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

in 1883 and later its vice-president. He was made an Honorary Fellow of the

Royal Society of Edinburgh The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established i ...

in 1916. Langley is known as one of the fathers of the

chemical receptor A chemoreceptor, also known as chemosensor, is a specialized sensory receptor which transduces a chemical substance (endogenous or induced) to generate a biological signal. This signal may be in the form of an action potential, if the chemorecept ...

theory, and as the origin of the concept of "receptive substance". In 1901, he advanced research in

neurotransmitter A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell. Neuro ...

s and chemical receptors, working with extracts from adrenal glands. These extracts elicited responses in tissues that were similar to those induced by nerve stimulation. He coined the term "

autonomic nervous system The autonomic nervous system (ANS), formerly referred to as the vegetative nervous system, is a division of the peripheral nervous system that supplies viscera, internal organs, smooth muscle and glands. The autonomic nervous system is a control ...

" (ANS) in 1898. He was the first person who put forward the concept of

parasympathetic nervous system The parasympathetic nervous system (PSNS) is one of the three divisions of the autonomic nervous system, the others being the sympathetic nervous system and the enteric nervous system. The enteric nervous system is sometimes considered part of ...

as a division of the ANS in 1921. He died in

Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...

on 5 November 1925.

Publications

*''The Autonomic Nervous System'' (1921) *''Elementary Experimental Physiology''

Recognition

A brass plaque to Langley's memory exists in Trinity College Chapel at Cambridge University.

Family

Langley married at St. Mary′s church, Montrose, on 10 September 1902 Vera Kathleen Forsythe-Grant (d.1932), third daughter of Frederick Grant Forsyth-Grant, of

Ecclesgreig St Cyrus or Saint Cyrus ( sco, Saunt Ceerus), formerly Ecclesgreig (from gd, Eaglais Chiric) is a village in the far south of Aberdeenshire, Scotland. General information Traditional salmon fishing with nets is still conducted from St Cyrus bea ...

Kincardineshire Kincardineshire, also known as the Mearns (from the Scottish Gaelic meaning "the Stewartry"), is a historic county, registration county and lieutenancy area on the coast of northeast Scotland. It is bounded by Aberdeenshire on the north and w ...

References

Bibliography

*Katz, B. (1986). "Archibald Vivian Hill", ''

Dictionary of National Biography The ''Dictionary of National Biography'' (''DNB'') is a standard work of reference on notable figures from British history, published since 1885. The updated ''Oxford Dictionary of National Biography'' (''ODNB'') was published on 23 September ...

'', Oxford University Press, Oxford, p. 406 {{DEFAULTSORT:Langley, John Newport 1852 births 1925 deaths Royal Medal winners Fellows of the Royal Society British physiologists People from Newbury, Berkshire Professors of Physiology (Cambridge) Alumni of St John's College, Cambridge The Journal of Physiology editors Members of the Royal Society of Sciences in Uppsala