John Middleton may refer to:

Politicians

*John Middleton (c.1373–1441), MP for Northumberland (UK Parliament constituency), Northumberland *John Middleton (MP for Horsham) (died 1636), English landowner and politician *John Middleton (1671–1745), Bramber (UK Parliament constituency), Member for Bramber and Horsham *John Middleton (British Army officer) (1678–1739), Brigadier-General, Member for Aberdeen *John Myddelton (1685–1747), MP for Denbigh Boroughs 1733–1741 and Denbighshire 1741–1742 *Sir John Middleton (colonial administrator) (1870–1954), British colonial administrator

Sportsmen

*John Middleton (baseball) (1900–1986), American baseball player *John Middleton (cyclist) (1906–1991), British racing cyclist *John Middleton (footballer, born 1910) (1910–1971), English football player for Swansea Town, Darlington, Blackpool and Norwich City *John Middleton (footballer, born 1955), English football player for Bradford City and Macclesfield *John Middleton (footballer, born 1956) (1956–2016), English football player for Nottingham Forest and Derby County *John Middleton (cricketer) (1890–1966), English cricketer *John R. Middleton, American football player and coach

Other people

*John Middleton (giant) (1578–1623), 2.8m tall man from Hale, England *John Middleton (explorer), travelled to the East Indies with James Lancaster, 1601–1603 *John Middleton, 1st Earl of Middleton (1608–1674), general in the Battle of Cropredy Bridge during the English Civil War *John Izard Middleton (1785–1849), American archeologist and artist *John Middleton (architect) (1820–1885), English architect *John Middleton (artist), Northern Irish artist, see ''The Honest Ulsterman'' *John Henry Middleton (1846–1896), archaeologist and museum director *John Middleton (cowboy) (1854–1885), member of the Regulators alongside Billy the Kid during the Lincoln County War *John Francis Marchment Middleton (1921–2009), British anthropologist *John Middleton (actor) (born 1953), English actor *John Powers Middleton (born 1984), American film and television producer *John S. Middleton, American businessman and philanthropist *John Middleton (Norfolk artist) (1827–1856), English artist *John Middleton (Commentator)(born 1977), English Commentator, Radio Presenter, Producer and Podcaster

Other uses

*John Middleton Co., a tobacco manufacturer and subsidiary of Altria {{dab Human name disambiguation pages, Middleton, John