Sir John Cowdery Kendrew,
(24 March 1917 – 23 August 1997) was an
English
English usually refers to:
* English language
* English people
English may also refer to:
Peoples, culture, and language
* ''English'', an adjective for something of, from, or related to England
** English national ide ...
biochemist
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...
,
crystallographer, and science administrator. Kendrew shared the 1962
Nobel Prize in Chemistry
)
, image = Nobel Prize.png
, alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...
with
Max Perutz
Max Ferdinand Perutz (19 May 1914 – 6 February 2002) was an Austrian-born British molecular biologist, who shared the 1962 Nobel Prize for Chemistry with John Kendrew, for their studies of the structures of haemoglobin and myoglobin. He went ...
, for their work at the
Cavendish Laboratory to investigate the structure of
heme
Heme, or haem (pronounced / hi:m/ ), is a precursor to hemoglobin, which is necessary to bind oxygen in the bloodstream. Heme is biosynthesized in both the bone marrow and the liver.
In biochemical terms, heme is a coordination complex "consisti ...
-containing
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
s.
Education and early life
Kendrew was born in
Oxford
Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the ...
, son of
Wilfrid George Kendrew
Wilfrid George Kendrew (12 September 1884 – 4 April 1962) was a British climatologist.
Early life
Kendrew was born in Keith, Banffshire in northern Scotland in 1884. His father was a customs officer who soon moved the family to Dublin. Kendrew ...
,
reader
A reader is a person who reads. It may also refer to:
Computing and technology
* Adobe Reader (now Adobe Acrobat), a PDF reader
* Bible Reader for Palm, a discontinued PDA application
* A card reader, for extracting data from various forms of ...
in
climatology
Climatology (from Greek , ''klima'', "place, zone"; and , '' -logia'') or climate science is the scientific study of Earth's climate, typically defined as weather conditions averaged over a period of at least 30 years. This modern field of stud ...
in the
University of Oxford
, mottoeng = The Lord is my light
, established =
, endowment = £6.1 billion (including colleges) (2019)
, budget = £2.145 billion (2019–20)
, chancellor ...
, and
Evelyn May Graham Sandburg, art historian. After prep school at the
Dragon School
("Reach for the Sun")
, established = 1877
, closed =
, type = Preparatory day and boarding school and Pre-Prep school
, religion = Church of England
, president =
, head_label = Head
, head = Emma Goldsm ...
in Oxford, he was educated at
Clifton College
''The spirit nourishes within''
, established = 160 years ago
, closed =
, type = Public schoolIndependent boarding and day school
, religion = Christian
, president =
, head_label = Head of College
, head ...
in
Bristol
Bristol () is a city, ceremonial county and unitary authority in England. Situated on the River Avon, it is bordered by the ceremonial counties of Gloucestershire to the north and Somerset to the south. Bristol is the most populous city in ...
, 1930–1936. He attended
Trinity College Trinity College may refer to:
Australia
* Trinity Anglican College, an Anglican coeducational primary and secondary school in , New South Wales
* Trinity Catholic College, Auburn, a coeducational school in the inner-western suburbs of Sydney, New ...
,
Cambridge
Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...
in 1936, as a Major Scholar, graduating in chemistry in 1939. He spent the early months of
World War II
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...
doing research on reaction kinetics, and then became a member of the Air Ministry Research Establishment, working on
radar
Radar is a detection system that uses radio waves to determine the distance (''ranging''), angle, and radial velocity of objects relative to the site. It can be used to detect aircraft, ships, spacecraft, guided missiles, motor vehicles, w ...
. In 1940 he became engaged in operational research at the
Royal Air Force
The Royal Air Force (RAF) is the United Kingdom's air and space force. It was formed towards the end of the First World War on 1 April 1918, becoming the first independent air force in the world, by regrouping the Royal Flying Corps (RFC) and ...
headquarters; commissioned a
squadron leader
Squadron leader (Sqn Ldr in the RAF ; SQNLDR in the RAAF and RNZAF; formerly sometimes S/L in all services) is a commissioned rank in the Royal Air Force and the air forces of many countries which have historical British influence. It is also ...
on 17 September 1941, he was appointed an honorary wing commander on 8 June 1944, and relinquished his commission on 5 June 1945. He was awarded his PhD after the war in 1949.
Research and career
During the war years, he became increasingly interested in biochemical problems, and decided to work on the structure of proteins.
Crystallography
In 1945 he approached
Max Perutz
Max Ferdinand Perutz (19 May 1914 – 6 February 2002) was an Austrian-born British molecular biologist, who shared the 1962 Nobel Prize for Chemistry with John Kendrew, for their studies of the structures of haemoglobin and myoglobin. He went ...
in the
Cavendish Laboratory in
Cambridge
Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...
.
Joseph Barcroft, a respiratory physiologist, suggested he might make a comparative protein crystallographic study of adult and fetal sheep
hemoglobin
Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocyte ...
, and he started that work.
In 1947 he became a Fellow of
Peterhouse
Peterhouse is the oldest constituent college of the University of Cambridge in England, founded in 1284 by Hugh de Balsham, Bishop of Ely. Today, Peterhouse has 254 undergraduates, 116 full-time graduate students and 54 fellows. It is quite o ...
; and the
Medical Research Council (MRC) agreed to create a research unit for the study of the molecular structure of biological systems, under the direction of Sir
Lawrence Bragg
Sir William Lawrence Bragg, (31 March 1890 – 1 July 1971) was an Australian-born British physicist and X-ray crystallography, X-ray crystallographer, discoverer (1912) of Bragg's law, Bragg's law of X-ray diffraction, which is basic for t ...
. In 1954 he became a Reader at the Davy-Faraday Laboratory of the
Royal Institution in
London
London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a majo ...
.
Crystal structure of myoglobin
![KendrewMyoglobin](https://upload.wikimedia.org/wikipedia/commons/e/ec/KendrewMyoglobin.jpg)
Kendrew shared the 1962
Nobel Prize
The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...
for
chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...
with
Max Perutz
Max Ferdinand Perutz (19 May 1914 – 6 February 2002) was an Austrian-born British molecular biologist, who shared the 1962 Nobel Prize for Chemistry with John Kendrew, for their studies of the structures of haemoglobin and myoglobin. He went ...
for determining the first atomic structures of
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
s using
X-ray crystallography
X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles ...
. Their work was done at what is now the
MRC Laboratory of Molecular Biology
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...
in
Cambridge
Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...
. Kendrew determined the structure of the protein
myoglobin
Myoglobin (symbol Mb or MB) is an iron- and oxygen-binding protein found in the cardiac and skeletal muscle tissue of vertebrates in general and in almost all mammals. Myoglobin is distantly related to hemoglobin. Compared to hemoglobin, myoglobi ...
, which stores oxygen in
muscle
Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscl ...
cells.
On Saturday 20 October 1962 the award of Nobel prizes to John Kendrew and Max Perutz, and to Crick, Watson, and Wilkins was satirised in a short sketch in the BBC TV programme ''
That Was The Week That Was
''That Was the Week That Was'', informally ''TWTWTW'' or ''TW3'', is a satirical television comedy programme that aired on BBC Television in 1962 and 1963. It was devised, produced, and directed by Ned Sherrin and Jack (aka John) Duncan, and pre ...
'' with the Nobel Prizes being referred to as 'The Alfred Nobel Peace Pools'.
In 1947 the MRC agreed to make a research unit for the Study of the Molecular Structure of Biological Systems. The original studies were on the structure of sheep
hemoglobin
Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocyte ...
, but when this work had progressed as far as was possible using the resources then available, Kendrew embarked on the study of
myoglobin
Myoglobin (symbol Mb or MB) is an iron- and oxygen-binding protein found in the cardiac and skeletal muscle tissue of vertebrates in general and in almost all mammals. Myoglobin is distantly related to hemoglobin. Compared to hemoglobin, myoglobi ...
, a molecule only a quarter the size of the hemoglobin molecule. His initial source of raw material was
horse
The horse (''Equus ferus caballus'') is a domesticated, one-toed, hoofed mammal. It belongs to the taxonomic family Equidae and is one of two extant subspecies of ''Equus ferus''. The horse has evolved over the past 45 to 55 million y ...
heart, but the crystals thus obtained were too small for X-ray analysis. Kendrew realized that the oxygen-conserving tissue of
diving mammals could offer a better prospect, and a chance encounter led to his acquiring a large chunk of
whale meat
Whale meat, broadly speaking, may include all cetaceans (whales, dolphins, porpoises) and all parts of the animal: muscle (meat), organs (offal), skin (muktuk), and fat (blubber). There is relatively little demand for whale meat, compared to ...
from Peru. Whale myoglobin did give large crystals with clean X-ray diffraction patterns.
However, the problem still remained insurmountable, until in 1953
Max Perutz
Max Ferdinand Perutz (19 May 1914 – 6 February 2002) was an Austrian-born British molecular biologist, who shared the 1962 Nobel Prize for Chemistry with John Kendrew, for their studies of the structures of haemoglobin and myoglobin. He went ...
discovered that the
phase problem
In physics, the phase problem is the problem of loss of information concerning the phase that can occur when making a physical measurement. The name comes from the field of X-ray crystallography, where the phase problem has to be solved for the det ...
in analysis of the diffraction patterns could be solved by
multiple isomorphous replacement Multiple isomorphous replacement (MIR) is historically the most common approach to solving the phase problem in X-ray crystallography studies of proteins. For protein crystals this method is conducted by soaking the crystal of a sample to be analyz ...
— comparison of patterns from several crystals; one from the native protein, and others that had been soaked in solutions of heavy metals and had metal ions introduced in different well-defined positions. An electron density map at 6
angstrom
The angstromEntry "angstrom" in the Oxford online dictionary. Retrieved on 2019-03-02 from https://en.oxforddictionaries.com/definition/angstrom.Entry "angstrom" in the Merriam-Webster online dictionary. Retrieved on 2019-03-02 from https://www.m ...
(0.6
nanometre
330px, Different lengths as in respect to the molecular scale.
The nanometre (international spelling as used by the International Bureau of Weights and Measures; SI symbol: nm) or nanometer (American and British English spelling differences#-re ...
) resolution was obtained by 1957, and by 1959 an atomic model could be built at 2 angstrom (0.2 nm) resolution.
Later career
In 1963, Kendrew became one of the founders of the
European Molecular Biology Organization
The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...
; as well, he founded and was for many years editor-in-chief of the
Journal of Molecular Biology
The ''Journal of Molecular Biology'' is a biweekly peer-reviewed scientific journal covering all aspects of molecular biology. It was established in 1959 and is published by Elsevier. The editor-in-chief is Peter Wright ( The Scripps Research In ...
. He became Fellow of the American Society of Biological Chemists in 1967 and honorary member of the International Academy of Science, Munich. In 1974, he succeeded in persuading governments to establish the
European Molecular Biology Laboratory
The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 27 member states, two prospect states, and one associate member state. EMBL was created in 1974 and ...
(EMBL) in
Heidelberg
Heidelberg (; Palatine German language, Palatine German: ''Heidlberg'') is a city in the States of Germany, German state of Baden-Württemberg, situated on the river Neckar in south-west Germany. As of the 2016 census, its population was 159,914 ...
and became its first director. He was knighted in 1974.
From 1974 to 1979, he was a Trustee of the
British Museum
The British Museum is a public museum dedicated to human history, art and culture located in the Bloomsbury area of London. Its permanent collection of eight million works is among the largest and most comprehensive in existence. It docum ...
, and from 1974 to 1988 he was successively Secretary General, Vice-President, and President of the
International Council of Scientific Unions
The International Council for Science (ICSU, after its former name, International Council of Scientific Unions) was an international non-governmental organization devoted to international cooperation in the advancement of science. Its members ...
.
After his retirement from EMBL, Kendrew became President of
St John's College at the
University of Oxford
, mottoeng = The Lord is my light
, established =
, endowment = £6.1 billion (including colleges) (2019)
, budget = £2.145 billion (2019–20)
, chancellor ...
, a post he held from 1981 to 1987. In his will, he designated his bequest to St John's College for studentships in science and in music, for students from developing countries. The ''Kendrew Quadrangle'' at St John's College in Oxford, officially opened on 16 October 2010, is named after him.
Kendrew was married to the former Elizabeth Jarvie (née Gorvin) from 1948 to 1956. Their marriage ended in divorce. Kendrew was subsequently partners with the artist Ruth Harris.
He left no survivors.
A biography of John Kendrew, titled ''A Place in History: The Biography of John C. Kendrew'', by
Paul M Wassarman was published by
Oxford University Press
Oxford University Press (OUP) is the university press of the University of Oxford. It is the largest university press in the world, and its printing history dates back to the 1480s. Having been officially granted the legal right to print books ...
in March 2020.
Selected Publications by Kendrew
*
*
*
*
*
*
*
*
*
*
*
References
Further reading
* John Finch; 'A Nobel Fellow on Every Floor', Medical Research Council 2008, 381 pp, ; this book is all about the MRC Laboratory of Molecular Biology, Cambridge.
Oxford University Press, page on Paul M. Wassarman, ''A Place in History'' , 2020
External links
*
*
{{DEFAULTSORT:Kendrew, John Cowdery
1917 births
1997 deaths
Alumni of Trinity College, Cambridge
Commanders of the Order of the British Empire
British crystallographers
English biologists
English biophysicists
English molecular biologists
English Nobel laureates
Fellows of the Royal Society
Foreign associates of the National Academy of Sciences
Knights Bachelor
Members of the European Molecular Biology Organization
Nobel laureates in Chemistry
People educated at Clifton College
People educated at The Dragon School
Scientists from Oxford
Presidents of St John's College, Oxford
Presidents of the British Science Association
Royal Medal winners
Trustees of the British Museum
X-ray crystallography
20th-century biologists
Royal Air Force personnel of World War II
Royal Air Force Volunteer Reserve personnel of World War II
Royal Air Force wing commanders