John F. Hartwig is an American organometallic chemist who holds the position of

Henry Rapoport Henry Rapoport (November 16, 1918 – March 6, 2002) was an internationally renowned organic chemistry, organic chemist and Professor of Chemistry at the University of California, Berkeley. He is widely recognized for his work in the development ...

Professor of

Chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...

at the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

. His laboratory traditionally focuses on developing transition metal-catalyzed reactions. Hartwig is known for helping develop the

Buchwald–Hartwig amination In organic chemistry, the Buchwald–Hartwig amination is a chemical reaction for the synthesis of carbon–nitrogen bonds via the cross-coupling reaction, palladium-catalyzed coupling reactions of amines with aryl halides. Although Pd-catalyzed ...

, a

chemical reaction A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...

used in

organic chemistry Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...

for the synthesis of carbon–nitrogen bonds via the palladium-catalyzed cross-coupling of

amines In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen atoms have been replaced by a substituent such ...

with

aryl halides In organic chemistry, an aryl halide (also known as haloarene) is an aromatic compound in which one or more hydrogen atoms, directly bonded to an aromatic ring are replaced by a halide. The haloarene are different from haloalkanes because they exhi ...

Education and training

Hartwig received his A.B. from

Princeton University Princeton University is a private university, private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest ins ...

in 1986. With

Robert G. Bergman Robert George Bergman is an American chemist. He is Professor of the Graduate School and Gerald E. K. Branch Distinguished Professor Emeritus at the University of California, Berkeley. Early life and education Born in Chicago, Robert Bergm ...

and Richard A. Andersen as coadvisors, he earned his Ph.D. from the

in 1990. Thereafter he was an American Cancer Society Postdoctoral Associate at MIT, where he worked in the laboratory of

Stephen J. Lippard Stephen James Lippard (born October 12, 1940) is the Arthur Amos Noyes Emeritus Professor of Chemistry at the Massachusetts Institute of Technology. He is considered one of the founders of bioinorganic chemistry, studying the interactions of ...

Research

He assumed an independent position at Yale University in 1992. Over the next 14 years, he was promoted to associate professor, full professor and finally the Irénée duPont professorship. During this period, the

was developed. Here is an example of this reaction (OTf =

triflate In organic chemistry, triflate (systematic name: trifluoromethanesulfonate), is a functional group with the formula and structure . The triflate group is often represented by , as opposed to −Tf, which is the triflyl group, . For example, ' ...

or trifluoromethanesulfonate): Buchwaldhartwig

Also while at Yale, he discovered the metal-catalyzed borylation of unactivated C-H bonds. Aliphatic C-H borylation-3

In 2006, he assumed the Kenneth L. Reinhart Jr. professorship at the

University of Illinois at Urbana–Champaign The University of Illinois Urbana-Champaign (U of I, Illinois, University of Illinois, or UIUC) is a public land-grant research university in Illinois in the twin cities of Champaign and Urbana. It is the flagship institution of the Universit ...

. There he published "Organotransition Metal Chemistry: From Bonding to Catalysis." In 2011 he returned to Berkeley as Henry Rapoport Professor of Chemistry as well as a member of the

Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory (LBNL), commonly referred to as the Berkeley Lab, is a United States Department of Energy National Labs, United States national laboratory that is owned by, and conducts scientific research on behalf of, t ...

. He was elected to the National Academy of Sciences in 2012. In 2019, together with Stephen Buchwald, he was awarded the Wolf Prize.

Memberships, fellowships, and awards

References

{{DEFAULTSORT:Hartwig, John UC Berkeley College of Chemistry faculty 21st-century American chemists Princeton University alumni 1964 births Living people Monsanto employees Organic chemists