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John Charles Cutler (June 29, 1915 – February 8, 2003) was a senior surgeon, and the acting chief of the
venereal disease Sexually transmitted infections (STIs), also referred to as sexually transmitted diseases (STDs) and the older term venereal diseases, are infections that are Transmission (medicine), spread by Human sexual activity, sexual activity, especi ...
program in the
United States Public Health Service The United States Public Health Service (USPHS or PHS) is a collection of agencies of the Department of Health and Human Services concerned with public health, containing nine out of the department's twelve operating divisions. The Assistant S ...
. After his death, his involvement in several controversial and unethical medical studies of
syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, an ...
was revealed, including the
Guatemala Guatemala ( ; ), officially the Republic of Guatemala ( es, República de Guatemala, links=no), is a country in Central America. It is bordered to the north and west by Mexico; to the northeast by Belize and the Caribbean; to the east by H ...
and the
Tuskegee syphilis experiment The Tuskegee Study of Untreated Syphilis in the Negro Male (informally referred to as the Tuskegee Experiment or Tuskegee Syphilis Study) was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Cente ...
s.


Early life and education

Cutler was born on June 29, 1915, in
Cleveland Cleveland ( ), officially the City of Cleveland, is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located in the northeastern part of the state, it is situated along the southern shore of Lake Erie, across the U.S. ...
, Ohio, to Grace Amanda Allen and Glenn Allen Cutler. He graduated from
Western Reserve University Western may refer to: Places *Western, Nebraska, a village in the US *Western, New York, a town in the US * Western Creek, Tasmania, a locality in Australia *Western Junction, Tasmania, a locality in Australia *Western world, countries that i ...
Medical School in 1941, and joined the
Public Health Service In public relations and communication science, publics are groups of individual people, and the public (a.k.a. the general public) is the totality of such groupings. This is a different concept to the sociological concept of the ''Öffentlichkei ...
in 1942. In 1943 he worked as a medical officer in the U.S. Public Health Venereal Disease Research Laboratory on
Staten Island Staten Island ( ) is a borough of New York City, coextensive with Richmond County, in the U.S. state of New York. Located in the city's southwest portion, the borough is separated from New Jersey by the Arthur Kill and the Kill Van Kull an ...
.


Bioethics violations

Cutler oversaw the
Terre Haute prison experiments The Terre Haute prison experiments were conducted by Dr. John C. Cutler in 1943 and 1944 under Dr. John F. Mahoney, the head of the Venereal Disease Research Laboratory of the US Public Health Service, to determine the effectiveness of treatment ...
in 1943 and 1944, in which inmates at a federal penitentiary agreed to be injected with strains of
gonorrhea Gonorrhea, colloquially known as the clap, is a sexually transmitted infection (STI) caused by the bacterium '' Neisseria gonorrhoeae''. Infection may involve the genitals, mouth, or rectum. Infected men may experience pain or burning with ...
in return for $100, a certificate of merit, and a letter of commendation to the parole board. The experiments were discontinued when Cutler's supervisor determined that the method of inducing gonorrhea in humans was unreliable and could not provide meaningful tests of prophylactic agents. Cutler then resumed these experiments, conducted by the United States Public Health Service with funding from the United States
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
(NIH), as part of the
syphilis experiments in Guatemala The Guatemala syphilis experiments were United States-led Human subject research, human experiments conducted in Guatemala from 1946 to 1948. The experiments were led by physician John Charles Cutler, who also participated in the late stages of th ...
beginning in 1946, during which doctors deliberately infected an estimated 1500 to 5000 Guatemalans with syphilis without the informed consent of the subjects. Unwitting subjects of the experiments included orphans as young as nine,Rory Carroll
Guatemala victims of US syphilis study still haunted by the “devil’s experiment”
''
The Guardian ''The Guardian'' is a British daily newspaper. It was founded in 1821 as ''The Manchester Guardian'', and changed its name in 1959. Along with its sister papers ''The Observer'' and ''The Guardian Weekly'', ''The Guardian'' is part of the Gu ...
'', 8 June 2011.
as well as soldiers, prisoners and mental patients. Approximately half of those infected as part of the study were treated for the diseases they contracted. A total of 83 subjects died, though the exact relationship to the experiment remains undocumented. This study not only violated the Hippocratic Oath but it echoed
Nazi Nazism ( ; german: Nazismus), the common name in English for National Socialism (german: Nationalsozialismus, ), is the far-right totalitarian political ideology and practices associated with Adolf Hitler and the Nazi Party (NSDAP) in ...
crimes exposed around the same time at the
Nuremberg trials The Nuremberg trials were held by the Allies of World War II, Allies against representatives of the defeated Nazi Germany, for plotting and carrying out invasions of other countries, and other crimes, in World War II. Between 1939 and 1945 ...
. In 1954, Cutler was in charge of experiments at
Sing Sing Sing Sing Correctional Facility, formerly Ossining Correctional Facility, is a maximum-security prison operated by the New York State Department of Corrections and Community Supervision in the village of Ossining, New York. It is about north of ...
prison to determine whether a
vaccine A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifie ...
made from the killed syphilis
bacterium Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...
would protect prisoners against infection when he later exposed them to the bacterium. Those infected were later treated with
penicillin Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from ''Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using ...
. Cutler became assistant surgeon general in 1958. In the 1960s until November 1972, Cutler was involved in the ongoing
Tuskegee syphilis experiment The Tuskegee Study of Untreated Syphilis in the Negro Male (informally referred to as the Tuskegee Experiment or Tuskegee Syphilis Study) was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Cente ...
, during which several hundred
African-American African Americans (also referred to as Black Americans and Afro-Americans) are an Race and ethnicity in the United States, ethnic group consisting of Americans with partial or total ancestry from sub-Saharan Africa. The term "African American ...
men who had contracted syphilis were observed, but left untreated. In “The Deadly Deception”, the 1993 '' Nova'' documentary about the Tuskegee experiments, Cutler states, “It was important that they were supposedly untreated, and it would be undesirable to go ahead and use large amounts of penicillin to treat the disease, because you’d interfere with the study.” In 1967 Cutler was appointed Professor of International Health at the
University of Pittsburgh The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the universit ...
, where he also served as chairman of the Department of Health Administration and acting dean of the Graduate School of Public Health in 1968–1969. He died on February 8, 2003 at
Western Pennsylvania Hospital The Western Pennsylvania Hospital, commonly referred to as "West Penn Hospital", is located at 4800 Friendship Avenue in the Bloomfield neighborhood of Pittsburgh, Pennsylvania. The 317-bed hospital is part of the Allegheny Health Network. It ser ...
in
Pittsburgh Pittsburgh ( ) is a city in the Commonwealth (U.S. state), Commonwealth of Pennsylvania, United States, and the county seat of Allegheny County, Pennsylvania, Allegheny County. It is the most populous city in both Allegheny County and Wester ...
. The university started a lecture series in his name after his death, but discontinued it in 2008 when his role in the Tuskegee experiment came to the attention of a new dean.Torsten Ove:
Presidential panel excoriates former Pitt dean
, ''Pittsburgh Post-Gazette'', 29 August 2011


See also

*
List of medical ethics cases Some cases have been remarkable for starting broad discussion and for setting precedent in medical ethics Medical ethics is an applied branch of ethics which analyzes the practice of clinical medicine and related scientific research. Medical eth ...


References

{{DEFAULTSORT:Cutler, John Charles 1915 births 2003 deaths University of Pittsburgh faculty United States Public Health Service personnel Physicians from Cleveland Case Western Reserve University alumni Human subject research in the United States Medical ethics