Early life and education
In grade nine, she conducted an experiment in her house, using mice as a model organism to probe sex based differences in learning. Cardin pursued her undergraduate degree at Cornell University in Ithaca, New York where she majored in biological sciences and started conducting research in a real laboratory, instead of her own home. At Cornell, Cardin joined the lab of Timothy J. DeVoogd, where she studied learning in songbirds and mapped out the morphology and anatomy of the high vocal center (HVC) in female canaries. Her undergraduate research led to a publication in Brain Research where she helped to adapt a technique to morphologically define specific projection pathways to the high vocal center (HVC). They describe their discovery of neurons projecting to AreaX that receive direct auditory input to support the function of the HVC in song learning. After graduating with a B.A. fromResearch
During her graduate studies, Cardin explored the variability in sensory processing across brain states, such as during sedation, wakefulness, and high arousal. She found that behavioral states drastically influence the neural firing patterns of auditory neurons. While songbirds are asleep, the neurons in the HVC increase in firing, with selectivity towards the birds own song, while when songbirds are awake, there is much more variability in firing and there is no longer selectivity towards the bird's own song. They further found that arousal suppressed the responsiveness of the HVC which suggests that other mechanisms must be at play to enhance auditory responsiveness in awake states. After discovering that the HVC is modulated according to behavioral state, Cardin then found that an upstream brain area, called the (NiF) is also modulated by behavioral state. By pharmacologically inhibiting and exciting the NiF, Cardin found that the NiF is the primary integration site of behavioral state information and it relays this information to the HVC to drive its responsiveness to behavioral state. Following this study, Cardin showed that specifically the noradrenergic neurons in the NiF are what mediate NiF neuron responsiveness to brain state. Overall, Cardin's findings in graduate school highlight the noradrenergic neurons in the NiF as the critical integrators of brain state to relay state information during vocal learning in songbirds. In her postdoctoral work, Cardin explored gamma oscillations in the primary visual cortex of cats. She explored both simple and complex cells in the primary visual cortex and found that, while they both burst at gamma frequencies, only simple cells show a selective stimulus feature-dependent response to visual stimulation. Since rhythmic synaptic input drives visually evoked activity in both simple and complex fast rhythmic bursting cells of the visual cortex, Cardin proposes that these cells may distribute stimulus driven gamma oscillations throughout the neocortex. Following this paper, Cardin and her team validated the existence of gain modulation in the primary visual cortex. Gain modulation is a neural phenomenon in which response amplitude is modified without changing selectivity. Cardin and her team performed intracellular recordings in the cat primary visual cortex and found that gain modulation is determined instantaneously by the rapidly changing sensory context and the dynamics of synaptic activation. After focusing on the visual system, Cardin conducted a brief postdoctoral position atCareer
In 2010, Cardin was recruited to Yale University School of Medicine and became an assistant professor in the Department of Neurobiology. In 2012, she became a member of the Kavli Institute for Neuroscience at Yale. Cardin's lab probes cortical neural circuits to understand how cellular and synaptic interactions flexibly adapt to different behavioral states and environmental contexts to give rise to visual perceptions and drive motivated behaviors. Cardin's lab further applies their knowledge of adaptive cortical circuit regulation to probe how circuit dysfunction manifests in disease models. In addition to her roles in the lab, Cardin is on the Brain Science Mindscope Advisory Council as an Allen Institute Advisor and has been integrally involved in the organization and planning of the COSYNE Conference since 2009.Functional Flexibility in Neural Circuits
Cardin is interested in understanding how the brain can function without needing more neurons, specialized to specific behavioral states. Because neurons are able to so quickly respond and adapt to different environments and arousal states, Cardin and her team explored the neural activity governing transitions between distinct waking states. Heightened arousal states, compared to quiescent states, suppressed spontaneous neural firing and increased the signal to noise ratio of visual responses. Their findings pointed to the distinct behavior of neurons in different states and that the malleable activity patterns in cortical circuits are driven by both arousal state and locomotion in different ways. Following this study, Cardin and her team used in vivo calcium imaging to look at three distinct populations of projection neurons in the visual cortex to determine if they encoded and transferred unique information to downstream structures about the visual environment. They found that specific projection populations process and route visual information to downstream targets in functionally different ways to inform behavior. Cardin and her team recently probed the role of vasoactive intestinal peptide (VIP) expressing interneurons in cortical neural circuit regulation. By removing a critical signalling receptor, ErbB4, from VIP neurons, Cardin and her team saw deficits in sensory processing and dysregulation of cortical state dependence they had shown was important to cortical function in earlier experiments. Interestingly, the dysregulation in neural circuit function manifested in adolescence, even though ErbB4 was removed in development, suggesting that developmental aberrations in cortical circuit development might not present until later in life, mimicking the prognosis of many brain-related diseases and shedding insight into their possibly developmental origins.Awards and honors
* 2018 Allen Institute Distinguished Seminar Series * 2015 Smith Family Award for Excellence in Biomedical Research * 2014 McKnight Scholar Award * 2012 Alfred P. Sloan Fellowship * 2011 NARSAD Young Investigator Award * 2010 Klingenstein Fellowship Award in Neuroscience * 2005 Kirschtein Individual Postdoctoral NRSA Research Fellowship * 2004 Flexner Award for Outstanding Neuroscience Dissertation Research - University of Pennsylvania * 1996 Howard Hughes Undergraduate Scholar - Cornell UniversitySelect publications
* Miri ML, Vinck M, Pant R, Cardin J. Altered hippocampal interneuron activity precedes ictal onset. Elife. 7.References
{{DEFAULTSORT:Cardin, Jessica Living people Year of birth missing (living people) 21st-century American women scientists American neuroscientists American women academics Cornell University alumni Massachusetts Institute of Technology alumni University of Pennsylvania alumni Yale University faculty