Jerrold Schwaber (May 24, 1947 – June 6, 2014) was an American biologist and geneticist. In 1973 he described, with Edward Cohen, a method of producing

antibodies An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...

involving human–mouse hybrid cells, or

hybridomas Hybridoma technology is a method for producing large numbers of identical antibodies (also called monoclonal antibodies). This process starts by injecting a mouse (or other mammal) with an antigen that provokes an immune response. A type of whi ...

. They fused "mouse myeloma cells secreting immunoglobulin of known specificity and human peripheral blood lymphocytes not secreting detectable immunoglobulin. The hybrid cells continued secretion of mouse immunoglobulin and initiate synthesis and secretion of human immunoglobulin." The antibody producing cells did not survive long and the antigens that the antibodies targeted remained unknown.Dr Lara Marks for What is Biotechnology? A Healthcare Revolution in the Making: The Story of César Milstein and Monoclonal Antibodies
Making monoclonal antibodies
/ref> In 1975,

Georges Köhler Georges may refer to: Places * Georges River, New South Wales, Australia * Georges Quay (Dublin) *Georges Township, Fayette County, Pennsylvania Other uses *Georges (name) * ''Georges'' (novel), a novel by Alexandre Dumas * "Georges" (song), a 19 ...

César Milstein César Milstein, CH, FRS (8 October 1927 – 24 March 2002) was an Argentine biochemist in the field of antibody research. Milstein shared the Nobel Prize in Physiology or Medicine in 1984 with Niels Kaj Jerne and Georges J. F. Köhler for d ...

, and

Niels Kaj Jerne Niels Kaj Jerne, FRS (23 December 1911 – 7 October 1994) was a Danish immunologist. He shared the Nobel Prize in Physiology or Medicine in 1984 with Georges J. F. Köhler and César Milstein "for theories concerning the specificity in dev ...

, succeeded in making hybridomas that made antibodies to known antigens and that were immortalized. They shared the

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...

in 1984 for the discovery. His work in laying the foundation for modern

monoclonal antibody A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell Lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Monoclonal antibodies ca ...

technology is recognized.

Personal life

Jerrold Schwaber was born in Evanston, Illinois in 1947, the 3rd of 4 brothers. He received a Ph.D. from the University of Chicago in 1974. He died at his home in Haddonfield, NJ on June 6, 2014. He is survived by his wife, Susan Hoch MD, and his sons Jason and Jeff Schwaber. His brother,

Ken Schwaber Ken Schwaber (born 1945 in Wheaton, Illinois) is a software developer, product manager and industry consultant. He worked with Jeff Sutherland to formulate the initial versions of the Scrum framework and to present Scrum as a formal process ...

, is a software developer known for the invention of

Scrum Scrum may refer to: Sport * Scrum (rugby), a method of restarting play in rugby union and rugby league ** Scrum (rugby union), scrum in rugby union * Scrum, an offensive melee formation in Japanese game Bo-taoshi Media and popular culture * M ...

development process.

References

{{DEFAULTSORT:Schwaber, Jerrold American biologists 1947 births 2014 deaths