Jerome W. Conn (September 24, 1907 – June 11, 1994) was an American

endocrinologist Endocrinology (from ''endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events ...

best known for his description of

Conn syndrome Primary aldosteronism (PA)'','' also known as primary hyperaldosteronism or Conn's syndrome, refers to the excess production of the hormone aldosterone from the adrenal glands, resulting in low renin levels and high blood pressure. This abnormalit ...

or primary hyperaldosteronism.

Biography

Conn was born in

New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...

and studied for three years at

Rutgers University Rutgers University (; RU), officially Rutgers, The State University of New Jersey, is a Public university, public land-grant research university consisting of four campuses in New Jersey. Chartered in 1766, Rutgers was originally called Queen's ...

before he entered the

University of Michigan Medical School Michigan Medicine (University of Michigan Health System or UMHS before 2017) is the wholly owned academic medical center of the University of Michigan, a public research university in Ann Arbor, Michigan. Michigan Medicine includes the Universi ...

Ann Arbor Anne, alternatively spelled Ann, is a form of the Latin female given name Anna (name), Anna. This in turn is a representation of the Hebrew Hannah (given name), Hannah, which means 'favour' or 'grace'. Related names include Annie (given name), ...

in 1928. The

Great Depression The Great Depression (19291939) was an economic shock that impacted most countries across the world. It was a period of economic depression that became evident after a major fall in stock prices in the United States. The economic contagio ...

of 1929 made it hard for his family to support his education, but his sisters managed to pay for it with their salaries. He graduated with honors in 1932 and started an internship in

surgery Surgery ''cheirourgikē'' (composed of χείρ, "hand", and ἔργον, "work"), via la, chirurgiae, meaning "hand work". is a medical specialty that uses operative manual and instrumental techniques on a person to investigate or treat a pat ...

before switching to internal medicine. Conn worked at the Division of Clinical Investigation where he worked under Louis H. Newburgh on the relationship between

obesity Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's we ...

and non-insulin dependent

diabetes mellitus Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

. Conn proved that normal carbohydrate tolerance could be reached in twenty of twenty-one subjects when they reached normal weight. He became fellow in 1935 and assistant

professor Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who pr ...

in 1938. From 1943 Conn took on the Division of Endocrinology and started an investigation concerning acclimatization of military personnel to warm climates like in the South Pacific. He discovered that the excretion of

sodium Sodium is a chemical element with the symbol Na (from Latin ''natrium'') and atomic number 11. It is a soft, silvery-white, highly reactive metal. Sodium is an alkali metal, being in group 1 of the periodic table. Its only stable iso ...

sweat Perspiration, also known as sweating, is the production of fluids secreted by the sweat glands in the skin of mammals. Two types of sweat glands can be found in humans: eccrine glands and apocrine glands. The eccrine sweat glands are distribut ...

urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excretion, excreted from the body through the urethra. Cel ...

and

saliva Saliva (commonly referred to as spit) is an extracellular fluid produced and secreted by salivary glands in the mouth. In humans, saliva is around 99% water, plus electrolytes, mucus, white blood cells, epithelial cells (from which DNA can be ...

was curtailed in these circumstances. At the Presidential address to the Society of Clinical Research Conn presented a thirty-four-year-old patient complaining of episodic weakness of the lower legs, almost to paralysis, with periodic muscle spasms and cramps in her hands for a total period of seven years. After extensive research he had found a condition he called primary hyperaldosteronism, later called Conn syndrome. There were elevated levels of aldosterone in her circulation, coming from a hormone producing

adrenal The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol. They are found above the kidneys. Each gland has an outer cortex which ...

adenoma An adenoma is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or both. Adenomas can grow from many glandular organs, including the adrenal glands, pituitary gland, thyroid, prostate, and others. Some adenom ...

. Conn wrote a total of 284 articles and book chapters and was recognized as a tutor stimulating others in research. His clinic was leading for years after in research on hyperaldosteronism. Conn was honored by being named L. H. Newburgh Distinguished University Professor in 1968. There were many other honors during his career; he was member of twelve national professional societies. His retirement was in 1974. He died in

Naples, Florida Naples is a city in Collier County, Florida, United States. As of the 2020 census, the population of the historical city (i.e. in the immediate vicinity of downtown Naples) was 19,115. Naples is a principal city of the Naples-Marco Island, Flori ...

References

Who Named It?; Jerome W. Conn
{{DEFAULTSORT:Conn, Jerome W. 1907 births 1994 deaths Physicians from New York City American endocrinologists University of Michigan Medical School alumni 20th-century American physicians Members of the National Academy of Medicine