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Jeffrey Karp (born 1975) is a Canadian
biomedical engineer Biomedicine (also referred to as Western medicine, mainstream medicine or conventional medicine)
working as a Professor of Medicine at
Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...
,
Brigham and Women's Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts Gener ...
, and the principal faculty at the Harvard Stem Cell Institute and Affiliate Faculty at the
Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...
through the Harvard–MIT Division of Health Sciences and Technology. He is also an affiliate faculty at the
Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, Cambridge, Massachusetts, U ...
.


Education

Karp was born and raised in
Peterborough, Ontario Peterborough ( ) is a city on the Otonabee River in Ontario, Canada, about 125 kilometres (78 miles) northeast of Toronto. According to the 2021 Census, the population of the City of Peterborough was 83,651. The population of the Peterborough ...
. He graduated from
McGill University McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec, Canada. Founded in 1821 by royal charter granted by King George IV,Frost, Stanley Brice. ''McGill Universit ...
in 1999 with a degree in chemical engineering. While at McGill he also co-founded the McGill Engineering Code of Ethics "The Blueprint". He received a
Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is a ...
in Chemical and Biomedical Engineering from the
University of Toronto The University of Toronto (UToronto or U of T) is a public research university in Toronto, Ontario, Canada, located on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution ...
in 2004. From 2004 until 2006, Karp was a postdoctoral fellow in
Robert Langer Robert Samuel Langer Jr. FREng (born August 29, 1948) is an American chemical engineer, scientist, entrepreneur, inventor and one of the twelve Institute Professors at the Massachusetts Institute of Technology. He was formerly the Germeshau ...
's laboratory at MIT in the Harvard–MIT Program of Health Sciences and Technology; Karp had applied for the position but Langer had no funds to pay him, so Karp secured funding from the
Natural Sciences and Engineering Research Council The Natural Sciences and Engineering Research Council of Canada (NSERC; french: Conseil de recherches en sciences naturelles et en génie du Canada, CRSNG) is the major federal agency responsible for funding natural sciences and engineering rese ...
and Langer accepted him.


Research

In the Langer lab, Karp was inspired by another lab's publication in ''Nature'' that described adhesives based on the way that
gecko Geckos are small, mostly carnivorous lizards that have a wide distribution, found on every continent except Antarctica. Belonging to the infraorder Gekkota, geckos are found in warm climates throughout the world. They range from . Geckos ar ...
's feet stick to surfaces; he and Langer applied for funding from NSF to make medical adhesives based on geckos, and received the funding. In 2007 he received an appointment and his own lab at
Brigham and Women’s Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two f ...
, at a location near MIT; he retained his association with the Harvard–MIT HST program. He has made mentoring high school students, undergraduates, PhD students, and post docs a priority, and in 2008 he won the Outstanding Undergraduate Student Mentor Award at MIT, and in 2010 he won the Thomas A. McMahon Mentoring Award from the HST program. In 2013 the company Gecko Biomedical was founded based on the gecko adhesive work, as well as subsequent work done in the Karp lab based on secretions of sandcastle worms. In 2014 the company Skintifique was formed to commercialize a barrier cream Karp had invented to prevent skin reactions in people with
nickel allergy Nickel allergy or nickel allergic contact dermatitis (Ni-ACD) is a form of allergic contact dermatitis (ACD) caused by exposure to the chemical element nickel. It typically causes a rash that is red and itchy and that may be bumpy or scaly. The ...
. In 2015 the company Frequency Therapeutics was founded to create treatments for hearing loss based on work done by Langer and Karp inspired by the ability of some amphibians and birds to regrow hair cells that have been damaged. In 2016 the company Alivio Therapeutics was founded based on work by Langer and Karp on a hydrogel to deliver drugs, intended to stick to tissue and only release the drug in response to inflammation.


Recognition

''
Technology Review ''MIT Technology Review'' is a bimonthly magazine wholly owned by the Massachusetts Institute of Technology, and editorially independent of the university. It was founded in 1899 as ''The Technology Review'', and was re-launched without "The" in ...
'' listed him in 2008 as one of the top innovators under the age of 35 (
TR35 The Innovators Under 35 is a peer-reviewed annual award and listicle published by ''MIT Technology Review'' magazine, naming the world's top 35 innovators under the age of 35. at ''Technology Review'' with lists of winners at technologyreview.com ...
). Karp received the 2011 Young Investigator award from the Society for Biomaterials, and also in 2011, the ''
Boston Business Journal The ''Boston Business Journal'' is a weekly, business-oriented newspaper published in Boston, Massachusetts. It is published by the American City Business Journals. The newspaper was founded by Robert Bergenheim and launched its first issue on ...
'' profiled him as a Champion in Health Care Innovation.


References


External links

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TEDmed talk
{{DEFAULTSORT:Karp, Jeffrey American bioengineers Stem cell researchers Harvard Medical School faculty McGill University Faculty of Engineering alumni University of Toronto alumni People from Peterborough, Ontario Living people Fellows of the American Institute for Medical and Biological Engineering 1976 births