Jeffrey Drebin is a surgeon and scientist. He serves as the Department of Surgery Chair at

Memorial Sloan Kettering Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in the borough of Manhattan in New York City, founded in 1884 as the New York Cancer Hospital. MSKCC is one of 52 National Cancer Institute– ...

Biography

Drebin earned his MD and PhD from

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

, before completing his general surgery residency, and surgical oncology fellowship, at

Johns Hopkins Medical School The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hos ...

. His PhD research, performed with Mark Greene and Robert Weinberg, involved the creation of monoclonal antibodies targeting the

Her2/neu Receptor tyrosine-protein kinase erbB-2 is a protein that in humans is encoded by the ''ERBB2'' gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently refer ...

protein and demonstrating in preclinical models that such antibodies could inhibit

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

cell growth ''

in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called " test-tube experiments", these studies in biology ...

'' and ''

in vivo Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and ...

''. This work was focused on targeted cancer therapy and the creation of the drugs

trastuzumab Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together wi ...

(

Herceptin Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together wi ...

) and

pertuzumab Pertuzumab, sold under the brand name Perjeta, is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in earl ...

(

Perjeta Pertuzumab, sold under the brand name Perjeta, is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in ea ...

Career

In 1995, after finishing his residency, Drebin became an Assistant Professor of Surgery at

Washington University School of Medicine Washington University School of Medicine (WUSM) is the medical school of Washington University in St. Louis in St. Louis, Missouri. Founded in 1891, the School of Medicine has 1,260 students, 604 of which are pursuing a medical degree with ...

. He became an Associate Professor in 1999, and then a full Professor of Surgery and of

Molecular Biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

& Pharmacology in 2002. Drebin began working at Penn Medicine in 2004, when he was hired as Chief of the Division of Gastrointestinal Surgery. In 2009, he was named Chair of the Department. While there, he joined a

Stand Up to Cancer Stand Up to Cancer (SU2C) is a charitable program of the Entertainment Industry Foundation (EIF). SU2C aims to raise significant funds for translational cancer research through online and televised efforts. Central to the program is a telethon tha ...

“Dream Team” against pancreatic cancer as a co-Principal Investigator alongside Craig B. Thompson. In 2017, Drebin moved to Memorial Sloan Kettering to become Department of Surgery Chair. In addition to his responsibilities as Chair, he provides surgical treatments for patients with pancreatic, gallbladder, bile duct, liver, and stomach cancers. His research focuses on the development of new targeted therapies.

Other roles

* President, Society of Clinical Surgery (2010-2012) * President, Philadelphia Academy of Surgery (2014) * President, Society of Surgical Oncology (2015)

Awards

* American Association for Cancer Research Surgeon Scientist Award (2016) * Member, Institute of Medicine of the National Academy of Sciences (now the

National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Eng ...

) (2013) *

John Rhea Barton John Rhea Barton (April 1794 – January 1, 1871) was an American orthopedic surgeon remembered for describing Barton's fracture. Early life Barton was born in Lancaster, Pennsylvania in April 1794. He was the son of Elizabeth ( née Rhea) ...

Professorship (2009-2017)

References

External links

* https://www.mskcc.org/cancer-care/doctors/jeffrey-drebin {{DEFAULTSORT:Drebin, Jeffrey Cancer researchers American surgeons Memorial Sloan Kettering Cancer Center faculty Year of birth missing (living people) Living people Washington University in St. Louis faculty Harvard Medical School alumni Memorial Sloan Kettering Cancer Center physicians 20th-century American physicians 20th-century surgeons 21st-century American physicians 21st-century surgeons Members of the National Academy of Medicine