Jason H. Moore is a

translational bioinformatics Translational bioinformatics (TBI) is a field that emerged in the 2010s to study health informatics, focused on the convergence of molecular bioinformatics, biostatistics, statistical genetics and clinical informatics. Its focus is on applying in ...

scientist, biomedical informatician, and

human geneticist Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population g ...

, the Edward Rose Professor of Informatics and Director of the Institute for Biomedical Informatics at the Perelman School of Medicine at the

University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universitie ...

, where he is also Senior Associate Dean for Informatics and Director of the Division of Informatics in the Department of Biostatistics, Epidemiology, and Informatics.

Biography

He was a founding Director of the Advanced Computing Center for Research and Education at

Vanderbilt University Vanderbilt University (informally Vandy or VU) is a private research university in Nashville, Tennessee. Founded in 1873, it was named in honor of shipping and rail magnate Cornelius Vanderbilt, who provided the school its initial $1-million ...

from 2000 until 2004 and founding Director of the Institute for Quantitative Biomedical Sciences at Geisel School of Medicine of

Dartmouth College Dartmouth College (; ) is a private research university in Hanover, New Hampshire. Established in 1769 by Eleazar Wheelock, it is one of the nine colonial colleges chartered before the American Revolution. Although founded to educate Native A ...

from 2010 until 2015. He's been the editor-in-chief of the

BioData Mining ''BioData Mining'' is a peer-reviewed open access scientific journal covering data mining methods applied to computational biology and medicine established in 2008. It is published by BioMed Central and the editors-in-chief are Jason H. Moore a ...

journal since 2008.

Research

Moore's research focuses on the development and application of

artificial intelligence Artificial intelligence (AI) is intelligence—perceiving, synthesizing, and inferring information—demonstrated by machines, as opposed to intelligence displayed by animals and humans. Example tasks in which this is done include speech re ...

and

machine learning Machine learning (ML) is a field of inquiry devoted to understanding and building methods that 'learn', that is, methods that leverage data to improve performance on some set of tasks. It is seen as a part of artificial intelligence. Machine ...

methods for modeling complex patterns in biomedical

big data Though used sometimes loosely partly because of a lack of formal definition, the interpretation that seems to best describe Big data is the one associated with large body of information that we could not comprehend when used only in smaller am ...

. A central focus is using

informatics Informatics is the study of computational systems, especially those for data storage and retrieval. According to ACM ''Europe and'' ''Informatics Europe'', informatics is synonymous with computer science and computing as a profession, in which ...

methods for identifying combinations of DNA sequence variations and environmental factors that are predictive of human

health Health, according to the World Health Organization, is "a state of complete physical, mental and social well-being and not merely the absence of disease and infirmity".World Health Organization. (2006)''Constitution of the World Health Organiza ...

and

complex disease Multifactorial diseases are not confined to any specific pattern of single gene inheritance and are likely to be associated with multiple genes effects together with the effects of environmental factors. In fact, the terms ‘multifactorial’ and ...

. For example, he developed the

multifactor dimensionality reduction Multifactor dimensionality reduction (MDR) is a statistical approach, also used in machine learning automatic approaches, for detecting and characterizing combinations of attributes or independent variables that interact to influence a dependent o ...

(MDR) machine learning method for detecting and characterizing combinations of attributes or independent variables that interact to influence a dependent or class variable. He then applied MDR for an improved understanding of the interplay of multiple genetic polymorphisms of

complex traits Complex traits, also known as quantitative traits, are traits that do not behave according to simple Mendelian inheritance laws. More specifically, their inheritance cannot be explained by the genetic segregation of a single gene. Such traits show ...

in genome-wide association studies. More recent work focuses on computational methods such as the tree-based pipeline optimization tool (TPOT) for automated machine learning and

data science Data science is an interdisciplinary field that uses scientific methods, processes, algorithms and systems to extract or extrapolate knowledge and insights from noisy, structured and unstructured data, and apply knowledge from data across a br ...

. Current work also focuses on methods and software for accessible artificial intelligence. He is a former member of the

National Library of Medicine The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library. Located in Bethesda, Maryland, the NLM is an institute within the National Institutes of Health. Its ...

grant review committee (BLIRC). He is the founding Editor-in-Chief of the journal ''BioData Mining.'' He has published more than 500 peer-reviewed articles, book chapters and editorials. His translational bioinformatics research program has been continuously funded by multiple grants from the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

for nearly 20 years.

Honors

In 2011 he was elected as a Fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

(AAAS) and was selected as a Kavli Fellow of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

(NAS) in 2013. In 2015 he was elected a Fellow of the American College of Medical Informatics (ACMI). In 2017 he was elected a Fellow of the American Statistical Association (ASA). In 2021 he was elected a Fellow of the International Academy of Health Sciences Informatics (IAHSI). In 2021 he was elected a Member of the International Statistics Institute (ISI).

References

External links

Jason H. Moore's personal web page

Jason H. Moore's research laboratory at the University of Pennsylvania

Jason H. Moore's software on Github

Jason H. Moore's automated machine learning web page

Jason H. Moore's retrocomputing blog
* {{DEFAULTSORT:Moore, Jason H. Living people Health informaticians University of Michigan alumni Dartmouth College Florida State University alumni Vanderbilt University faculty University of Pennsylvania faculty American bioinformaticians Fellows of the American Statistical Association Year of birth missing (living people) Perelman School of Medicine at the University of Pennsylvania faculty