Jane Mellanby
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Jane H. F. Mellanby (14 April 1938 – 8 February 2021) was a British neuroscientist and academic. She was a doctoral student of biochemist Hans Krebs, and was a fellow at St. Hilda's College, Oxford from 1971 to 2006.


Early life

Mellanby was born in
Sheffield Sheffield is a city in South Yorkshire, England, whose name derives from the River Sheaf which runs through it. The city serves as the administrative centre of the City of Sheffield. It is historically part of the West Riding of Yorkshire a ...
, the daughter of entomologist
Kenneth Mellanby Major Kenneth Mellanby (26 March 1908 – 23 December 1993) was an English ecologist and entomologist. He received the OBE for his work on the scabies mite. Life and work lMellanby was educated at Barnard Castle School and then at King's Colleg ...
and Canadian-born biomedical researcher Agnes Helen Nielson Dow Mellanby. Her uncle was biochemist
Edward Mellanby Sir Edward Mellanby (8 April 1884 – 30 January 1955) was a British biochemist and nutritionist who discovered vitamin D and its role in preventing rickets in 1919. Education Mellanby was born in West Hartlepool, the son of a shipyard owner, ...
. She read botany, physiology and chemistry at Somerville College, Oxford. In 1962, she completed doctoral studies in biochemistry at Oxford with Hans Krebs as her advisor.


Career

Mellanby worked on
tetanospasmin Tetanus toxin (TeNT) is an extremely potent neurotoxin produced by the vegetative cell of ''Clostridium tetani'' in anaerobic conditions, causing tetanus. It has no known function for clostridia in the soil environment where they are normally ...
and botulinum toxins as a postdoctoral research associate at
Sir William Dunn School of Pathology The Sir William Dunn School of Pathology is a department within the University of Oxford. Its research programme includes the cellular and molecular biology of pathogens, the immune response, cancer and cardiovascular disease. It teaches undergra ...
. In 1970, she and Larry Weiskrantz founded the Neurochemistry unit in Oxford's Experimental Psychology department. She was a Fellow at St. Hilda's College, Oxford from 1971. From 1977 to 2006, she was an Official Fellow in Experimental Psychology at St. Hilda's; she was also vice-principal of the college, from 1990 to 1996. In 2016, she was elected an honorary fellow of the
Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...
. Mellanby's research included a focus on
temporal lobe epilepsy Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system which is characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes. TLE is the most common ...
. She took a particular interest in secondary education and served as a governor of a local comprehensive school. She helped to develop the VESPARCH test for evaluating verbal and spatial reasoning skills in students, as director of the Oxford Group For Children's Potential. She also studied gender differences in undergraduate science education. Her research appeared in academic journals including ''Nature'', ''Neuroscience'', ''Journal of Physiology,'' ''
Journal of Psychopharmacology The ''Journal of Psychopharmacology'' is a monthly peer-reviewed scientific journal published by Sage Publications on behalf of the British Association for Psychopharmacology. It was established in 1987 and is a member of the Committee on Public ...
'', ''
British Journal of Psychology The ''British Journal of Psychology'' is a quarterly peer-reviewed psychology journal. It was established in 1904 and is published by Wiley-Blackwell on behalf of the British Psychological Society. The editor-in-chief is Stefan R. Schweinberger ( ...
'', ''
Journal of Deaf Studies and Deaf Education The ''Journal of Deaf Studies and Deaf Education'' is a peer-reviewed academic journal covering basic and applied research relating to individuals who are deaf, including developmental, cultural, educational, and linguistic Linguistics is ...
'', ''
Higher Education Higher education is tertiary education leading to award of an academic degree. Higher education, also called post-secondary education, third-level or tertiary education, is an optional final stage of formal learning that occurs after comple ...
'', ''
Biochemical Journal The ''Biochemical Journal'' is a peer-reviewed scientific journal which covers all aspects of biochemistry, as well as cell and molecular biology. It is published by Portland Press and was established in 1906. History The journal was established ...
,'' and '' Medical Teacher''.


Publications

* "Enzymic determination of d(−)-β-hydroxybutyric acid and acetoacetic acid in blood" (1962, with Dermot H. Williamson and Hans A. Krebs) * "The equilibrium constant of the β-hydroxybutyric-dehydrogenase system" (1962, with Dermot H. Williamson and Hans A. Krebs) * "Specific Precocious Protective Action of Toxoids" (1964, with W. E. van Heyningen) * "The effect of tetanus toxin in the goldfish" (1971, with J. Diamond) * "The effect of tetanus toxin at the neuromuscular junction in the goldfish" (1972, with P. A. Thompson) * "A note on the specific fixation, specific deactivation and non-specific inactivation of bacterial toxins by
ganglioside A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. ''N''-acetylneuraminic acid, NANA) linked on the sugar chain. NeuNAc, an acetylated derivative of the carbohydrate si ...
s" (1973, with W. E. van Heyningen) * "D-(–)-3-Hydroxybutyrate" (1974, with Dermot H. Williamson) * "How does tetanus toxin act?" (1981, with Jane Green) * "The effect of Ro 15-4513, an inverse agonist at the benzodiazepine receptor, on the exploratory response to novelty in the playground maze" (1994, with Briony Nicholls and Stephen Smith) * "The 'gender gap' in final examination results at Oxford University" (2000, with Maryanne Martin and John O'Doherty) * "Attitudes to e-learning, learning style and achievement in learning neuroanatomy by medical students" (2008, with Elena Svirko) * "Deep learning questions can help selection of high ability candidates for universities" (2009, with Mario Cortino-Borja and John Stein) * "Verbal and Spatial Analogical Reasoning in Deaf and Hearing Children: The Role of Grammar and Vocabulary" (2011, with Lindsey Edwards, Berta Figueras, and Dawn Langdon) * "Trait anxiety and final degree performance at the University of Oxford" (2011, with Anna Zimdars) * ''Education and Learning: An Evidence–based Approach'' (2014, with Katy Theobald) * "Teaching neuroanatomy using computer-aided learning: What makes for successful outcomes?" (2017, with Elena Svirko)


Personal life

Mellanby married zoologist and curator Oliver R. Impey in 1961. They had four children, including
Edward Impey Edward Alexander Impey, (born 28 May 1962) is a British historian, archaeologist, and museum curator. Between October 2013 and January 2022 he was Master of the Armouries and Director General of the Royal Armouries. Early life and education Im ...
. She was widowed when Impey died in 2005; she died from cancer in 2021, aged 82 years.


References


External links


A portrait of Mellanby
by Emily Porter-Salmon
Acquisition of complex language in a changing society
(May 21, 2019), a Cambridge Assessment Network seminar with Professor Jane Mellanby, on YouTube {{DEFAULTSORT:Mellanby, Jane 1938 births 2021 deaths British women scientists British biochemists British neuroscientists People from Sheffield Fellows of St Hilda's College, Oxford Alumni of Somerville College, Oxford