James Nicholas may refer to:
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James A. Nicholas
James A. Nicholas (1921 – July 15, 2006) was an American orthopedic surgeon and a pioneer in the treatment of athletic injuries who was best known for performing four knee operations that saved the career of Hall of Fame quarterback Joe Namath. ...
, orthopedic surgeon
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James H. Nicholas, yeoman, settler and politician
{{hndis, Nicholas, James