James A. Spudich () is an American scientist and professor. He is the Douglass M. and Nola Leishman Professor of Biochemistry and of Cardiovascular Disease at

Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...

and works on the molecular basis of muscle contraction. He was awarded the Albert Lasker Basic Medical Research Award in 2012 with

Michael Sheetz Michael Patrick Sheetz is a cell biologist, a pioneer of mechanobiology and biomechanics, and a key contributor to the discovery of kinesin. He serves as the Robert A. Welch Distinguished University Chair in Chemistry at the University of Texas Med ...

and

Ronald Vale Ronald David Vale (born 1959) is a biochemist and cell biologist. He is a professor at the Department of Cellular and Molecular Pharmacology, University of California, San Francisco. His research is focused on motor proteins, particularly kinesi ...

. He is a Fellow of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

and a Member of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

Biography

He was born in

Benld Benld is a city in Macoupin County, Illinois, United States. The population was 1,464 at the 2020 census, down from 1,556 in 2010. It is located in the Metro-East portion of the Greater St. Louis metropolitan area. ''Benld'' was declared the " ...

Illinois Illinois ( ) is a U.S. state, state in the Midwestern United States, Midwestern United States. Its largest metropolitan areas include the Chicago metropolitan area, and the Metro East section, of Greater St. Louis. Other smaller metropolita ...

of Croatian ancestry. He earned his

B.S. A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University ...

in chemistry from

University of Illinois at Urbana-Champaign The University of Illinois Urbana-Champaign (U of I, Illinois, University of Illinois, or UIUC) is a public land-grant research university in Illinois in the twin cities of Champaign and Urbana. It is the flagship institution of the Univ ...

, where he worked in

John Woodland Hastings John Woodland "Woody" Hastings, (March 24, 1927 – August 6, 2014) was a leader in the field of photobiology, especially bioluminescence, and was one of the founders of the field of circadian biology (the study of circadian rhythms, or the slee ...

's lab on the topic of

bioluminescence Bioluminescence is the production and emission of light by living organisms. It is a form of chemiluminescence. Bioluminescence occurs widely in marine vertebrates and invertebrates, as well as in some fungi, microorganisms including some b ...

, and helped Hastings teach in the physiology course at the

Marine Biological Laboratory The Marine Biological Laboratory (MBL) is an international center for research and education in biological and environmental science. Founded in Woods Hole, Massachusetts, in 1888, the MBL is a private, nonprofit institution that was independent ...

Woods Hole Woods Hole is a census-designated place in the town of Falmouth in Barnstable County, Massachusetts, United States. It lies at the extreme southwest corner of Cape Cod, near Martha's Vineyard and the Elizabeth Islands. The population was 781 at ...

. He earned his Ph.D. in

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

from Stanford University under the guidance from

Arthur Kornberg Arthur Kornberg (March 3, 1918 – October 26, 2007) was an American biochemist who won the Nobel Prize in Physiology or Medicine 1959 for the discovery of "the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic ac ...

. He later did his

postdoctoral research A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to p ...

at Stanford University with

Charles Yanofsky Charles Yanofsky (April 17, 1925 – March 16, 2018) was an American geneticist on the faculty of Stanford University who contributed to the establishment of the one gene-one enzyme hypothesis and discovered attenuation, a riboswitch mechanis ...

and at MRC in the

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

with

Hugh Huxley Hugh Esmor Huxley MBE FRS (25 February 1924 – 25 July 2013) was a British molecular biologist who made important discoveries in the physiology of muscle. He was a graduate in physics from Christ's College, Cambridge. However, his education ...

. His research is focused on studying

molecular motors Molecular motors are natural (biological) or artificial molecular machines that are the essential agents of movement in living organisms. In general terms, a motor is a device that consumes energy in one form and converts it into motion or mech ...

particularly

myosin Myosins () are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. They are ATP-dependent and responsible for actin-based motility. The first myosin ...

. With Huxley, he started working on an actin/myosin/ ATP model for molecular motors, proposing that myosin would ratchet

actin Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of over ...

and exert a stroke. Spudich first attempted to create an

in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...

setup with actin and myosin. However, he faced great difficulty aligning actin filaments. In 1982 he and

started to work on the alga

Nitella ''Nitella'' is a genus of charophyte green algae in the family Characeae. Species The species in the genus include: *'' Nitella abyssinica'' A. Braun * '' Nitella acuminata'' A. Braun ex Wallman *'' Nitella aemula'' A. Braun * '' Nitella an ...

, which has long oriented actin fibers, and observed myosin coated beads moving along

filaments. This provided strong clues about the molecular transport of intracellular cargo, later refined to observing a single step of a single myosin molecule. His research and its place in the overal development of the motility field has been described in a number of well-cited review articles. He started at

UCSF The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It condu ...

and then came to Stanford as a professor of

Structural biology Structural biology is a field that is many centuries old which, and as defined by the Journal of Structural Biology, deals with structural analysis of living material (formed, composed of, and/or maintained and refined by living cells) at every le ...

in 1977. In 1992 he switched to the Department of

Biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

. In the late 1990s, he joined with Stanford physicist

Steven Chu Steven ChuStanford University Bio-X Initiative Stanford University, officially Leland Stanford Junior University, is a Private university, private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. S ...

and physically locates investigators from these distinct disciples together for extended periods. They pitched the concept to Stanford Provost

Condoleezza Rice Condoleezza Rice ( ; born November 14, 1954) is an American diplomat and political scientist who is the current director of the Hoover Institution at Stanford University. A member of the Republican Party, she previously served as the 66th Uni ...

. From 1994–1998 he was the editor of the ''

Annual Review of Cell and Developmental Biology The ''Annual Review of Cell and Developmental Biology'' is a peer-reviewed scientific journal published by Annual Reviews since 1985. It releases an annual volume of review articles relevant to the fields of cell biology and developmental biology. ...

''. In 1998 Spudich co-founded

Cytokinetics Cytokinetics, Inc. is a publicly traded biopharmaceutical company based in South San Francisco, California, that develops muscle activators and muscle inhibitors as potential treatments for people with diseases characterized by impaired or declin ...

Inc. in San Francisco, along with Ron Vale and James Sabry from

and Larry Goldstein from

UCSD The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Insti ...

. Spudich also co-founded MyoKardia in 2012 which was acquired by Bristol Myers Squibb in 2020 for $13.1 billion. In 2019, James Spudich, Annamma Spudich, Darshan Trivedi, Suman Nag and Kathleen Ruppel co-founded Kainomyx Inc. which is focused on treating neglected tropical diseases. He was the president of the

American Society for Cell Biology The American Society for Cell Biology (ASCB) is a professional society that was founded in 1960. Spudich's long-time recreational hobby is flying small planes.

Awards

Massry Prize The Massry Prize was established in 1996, and until 2009 was administered by the Meira and Shaul G. Massry Foundation. The Prize, of $40,000 and the Massry Lectureship, is bestowed upon scientists who have made substantial recent contributions in ...

2013 *

Lasker Award The Lasker Awards have been awarded annually since 1945 to living persons who have made major contributions to medical science or who have performed public service on behalf of medicine. They are administered by the Lasker Foundation, which was f ...

2012 *

Wiley Prize The Wiley Prize in Biomedical Sciences is intended to recognize breakthrough research in pure or applied life science research that is distinguished by its excellence, originality and impact on our understanding of biological systems and processes. ...

2012 * E. B. Wilson Medal 2011 *

Humboldt Prize The Humboldt Prize, the Humboldt-Forschungspreis in German, also known as the Humboldt Research Award, is an award given by the Alexander von Humboldt Foundation of Germany to internationally renowned scientists and scholars who work outside of G ...

1991

References

External links

Stanford Bio
{{DEFAULTSORT:Spudich, James American biochemists American biophysicists Living people Stanford University School of Medicine faculty Year of birth missing (living people) People from Macoupin County, Illinois University of Illinois Urbana-Champaign alumni Stanford University alumni American people of Croatian descent Recipients of the Albert Lasker Award for Basic Medical Research Members of the United States National Academy of Sciences Massry Prize recipients Cell biologists