Jacques Tréfouël
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Jacques Tréfouël (9 November 1897,
Le Raincy Le Raincy () is a prestigious commune in the eastern suburbs of Paris, France. It is located from the center of Paris. Le Raincy is a subprefecture of the Seine-Saint-Denis department and the seat of the Arrondissement of Le Raincy. Its populat ...
– 11 July 1977,
Paris Paris () is the capital and most populous city of France, with an estimated population of 2,165,423 residents in 2019 in an area of more than 105 km² (41 sq mi), making it the 30th most densely populated city in the world in 2020. S ...
) was a French medical chemist. He collaborated closely with his wife,
Thérèse Tréfouël Thérèse Tréfouël (née Boyer, 19 June 1892 — 9 November 1978) was a French chemist. Along with her husband, Jacques Tréfouël, she is best known for her research on sulfamides, a novel class of antibiotic drugs. Education and personal l ...
, including on the discovery of sulfanilamide.


Biography

From 1920 to 1928 he worked as an assistant to
Ernest Fourneau Ernest Fourneau (4 October 1872 – 5 August 1949) was a French pharmacist graduated in Pharmacy 1898 for the Paris university specialist in medicinal chemical and pharmacology who played a major role in the discovery of synthetic local anesthetic ...
in the laboratory of medicinal chemistry at the
Pasteur Institute The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines f ...
. For the next ten years, he served as laboratory chief at the Institute, during which time, he was involved in the synthesis and development of drugs such as stovarsol, orsanine and rhodoquine. In 1935, in collaboration with his wife, chemist
Thérèse Tréfouël Thérèse Tréfouël (née Boyer, 19 June 1892 — 9 November 1978) was a French chemist. Along with her husband, Jacques Tréfouël, she is best known for her research on sulfamides, a novel class of antibiotic drugs. Education and personal l ...
, and
pharmacologist Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
s
Daniel Bovet Daniel Bovet (23 March 1907 – 8 April 1992) was a Swiss-born Italian pharmacologist who won the 1957 Nobel Prize in Physiology or Medicine for his discovery of drugs that block the actions of specific neurotransmitters. He is best known for his ...
and Federico Nitti, he conducted research of
prontosil Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria. One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is ...
, of which, they demonstrated that only a portion of the substance, named sulphanilamide, was active against
streptococcus ''Streptococcus'' is a genus of gram-positive ' (plural ) or spherical bacteria that belongs to the family Streptococcaceae, within the order Lactobacillales (lactic acid bacteria), in the phylum Bacillota. Cell division in streptococci occurs ...
. The group also showed sulphanilamide's effective action against other types of bacteria (
meningococcus ''Neisseria meningitidis'', often referred to as meningococcus, is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening sepsis. The bacterium is referred to as a ...
,
pneumococcus ''Streptococcus pneumoniae'', or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic (under aerobic conditions) or beta-hemolytic (under anaerobic conditions), aerotolerant anaerobic member of the genus Streptococcus. They are ...
,
gonococcus ''Neisseria gonorrhoeae'', also known as ''gonococcus'' (singular), or ''gonococci'' (plural), is a species of Gram-negative diplococci bacteria isolated by Albert Neisser in 1879. It causes the sexually transmitted genitourinary infection gon ...
, Friedlander's bacillus, etc.).Repères chronologiques / Jacques Tréfouël (1897-1977)
Service des Archives de l'Institut Pasteur
In 1938 he was appointed head of the medicinal chemistry laboratory at the Pasteur Institute. From 1940 to 1964 he served as director of the Institute, while still retaining his role as head of the medicinal chemistry laboratory. He was a member of the
Société de pathologie exotique Lactalis is a French multinational dairy products corporation, owned by the Besnier family and based in Laval, Mayenne, France. The company's former name was Besnier SA. Lactalis is the largest dairy products group in the world, and is the se ...
(from 1927),
Société Philomathique de Paris The Philomaths, or Philomath Society ( pl, Filomaci or ''Towarzystwo Filomatów''; from the Greek φιλομαθεῖς "lovers of knowledge"), was a secret student organization that existed from 1817 to 1823 at the Imperial University of Vilniu ...
(from 1933), and from 1971 to 1977, served as president of the
Société de biologie The Société de biologie is a learned society founded in Paris in 1848. The society was conceived during the French Revolution of 1848. The members of the society held regular meetings and published the proceedings in a new scientific journal. The ...
. He was also a member of the
Académie de médecine An academy ( Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary or tertiary higher learning (and generally also research or honorary membership). The name traces back to Plato's school of philosophy ...
(president 1967) and the
Académie des sciences The French Academy of Sciences (French: ''Académie des sciences'') is a learned society, founded in 1666 by Louis XIV at the suggestion of Jean-Baptiste Colbert, to encourage and protect the spirit of French scientific research. It was at the ...
(president 1965).


Selected works

* ''Contribution à la chimiothérapie du paludisme. Essais sur la maladie des canaris'' (with E. Fourneau and T. Tréfouël), 1930 in: Annales de l’Institut Pasteur – Contributuion to the chemotherapy for
malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. S ...
. * ''Action antistreptococcique des dérivés sulfurés organiques'' (with E. Fourneau, T. Tréfouël, F. Nitti and D. Bovet), 1937 – Anti-streptococcal action of organic sulfur derivatives. * ''Le Sulfamide et ses dérivés : chimie, biologie, pharmacologie'', 1941 –
Sulfamide Sulfamide (IUPAC name: sulfuric diamide) is an organosulfur compound with the chemical formula and structure . Sulfamide is produced by the reaction of sulfuryl chloride with ammonia. Sulfamide was first prepared in 1838 by the French chemist ...
and its derivatives: chemistry, biology, pharmacology. * ''Titres et travaux scientifiques de Jacques Tréfouël'', 1942 – Titles and scientific work of Jacques Tréfouël. * ''Relations entre structure et propriétés thérapeutiques des dérivés organiques de l'arsenic pentavalent'', 1942 – Relationship between the structure and therapeutic properties of organic derivatives of
pentavalent In chemistry, the valence (US spelling) or valency (British spelling) of an element is the measure of its combining capacity with other atoms when it forms chemical compounds or molecules. Description The combining capacity, or affinity of a ...
arsenic Arsenic is a chemical element with the symbol As and atomic number 33. Arsenic occurs in many minerals, usually in combination with sulfur and metals, but also as a pure elemental crystal. Arsenic is a metalloid. It has various allotropes, but ...
. * ''Techniques de laboratoire : chimie physique, chimie biologique, chimie clinique'', 1947 – Laboratory techniques: physical chemistry, organic chemistry, clinical chemistry.Most widely held works by Jacques Tréfouël
WorldCat Identities


References

{{DEFAULTSORT:Trefouel, Jacques 1897 births 1977 deaths 20th-century French chemists French pharmacologists Members of the French Academy of Sciences People from Seine-Saint-Denis