Iacopo V Appiani (1480 – 20 October 1545) was the

lord of Piombino The Lordship of Piombino (''Signoria di Piombino''), and after 1594 the Principality of Piombino (''Principato di Piombino''), was a small state on the Italian peninsula centred on the city of Piombino and including part of the island of Elba. I ...

of the Appiani (or Appiano) dynasty from 1511 until his death. He was born in Piombino, the son of Iacopo IV Appiani, 1st Prince of Piombino and Princess Victoria Todeschini-Piccolomini. Iacopo V's paternal grandfather was Jacopo III, the 3rd lord of Piombino and Battistini Kampofregozo and of the daughter of Doge of Genoa Jano I. His maternal grandfather was Antonio, the 1st Duke of Amalfi from Todeschini-Piccolomini, and of Princess Mary d'Aragona, illegitimate daughter of the Ferdinand the Ist, the King of Naples. Like his predecessors, he initially allied with the Aragonese of Naples, in his case by marrying Marianna of Aragon in 1510, widow of Roberto II Sanseverino. After Marianna's death, he married Emilia Ridolfi, niece of Pope Leo X; she died soon afterwards, and Jacopo remarried with her sister Clarice. After her death he married a third time to Elena Salviati, daughter of

Jacopo Salviati Jacopo Salviati (15 September 1461 – 6 September 1533) was a Florentine politician and son-in-law of Lorenzo de' Medici. On 10 September 1486 he married Lorenzo's daughter Lucrezia de' Medici, with whom he had ten children. The son of Giovan ...

and

Lucrezia de' Medici Lucrezia de' Medici was the name for several women from the Medici family: *Lucrezia di Piero de' Medici (1447–1493), best known as Nannina de' Medici. *Lucrezia di Lorenzo de' Medici (August 4, 1470 – between November 10 and Novemb ...

. He is sometimes argued to be the subject of Rosso Fiorentino's '' Portrait of a Young Man'' (Berlin). He was succeeded by his son Iacopo VI. His other son Alfonso was admiral in the Navy of the

Grand Duchy of Tuscany The Grand Duchy of Tuscany ( it, Granducato di Toscana; la, Magnus Ducatus Etruriae) was an Italian monarchy that existed, with interruptions, from 1569 to 1859, replacing the Republic of Florence. The grand duchy's capital was Florence. In th ...

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