Jack Fishman
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Jack Fishman (September 30, 1930 – December 7, 2013), born Jacob Fiszman, was a Jewish-American
pharmaceutical A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field an ...
researcher from Kraków, Poland. In 1961, along with Mozes J. Lewenstein, he developed the medication
naloxone Naloxone, sold under the brand names Narcan (4 mg) and Kloxxado (8 mg) among others, is a medication used to reverse or reduce the effects of opioids. It is commonly used to counter decreased breathing in opioid overdose. Effects begin withi ...
, which can reverse an
opioid overdose An opioid overdose is toxicity due to excessive consumption of opioids, such as morphine, codeine, heroin, fentanyl, tramadol, and methadone. This preventable pathology can be fatal if it leads to respiratory depression, a lethal condition that ca ...
, and the
Centers for Disease Control and Prevention The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquartered in Atlanta, Georgi ...
has described as a "a life-saving medication that can reverse an overdose from opioids—including heroin, fentanyl, and prescription opioid medications."


Personal life

He fled the
Nazi occupation German-occupied Europe refers to the sovereign countries of Europe which were wholly or partly occupied and civil-occupied (including puppet governments) by the military forces and the government of Nazi Germany at various times between 1939 ...
of Poland with his parents when he was eight and spent much of his youth in
Shanghai Shanghai (; , , Standard Mandarin pronunciation: ) is one of the four direct-administered municipalities of the People's Republic of China (PRC). The city is located on the southern estuary of the Yangtze River, with the Huangpu River flowin ...
, where he attended a Jewish school. He emigrated to the
United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territori ...
at age 18. He was married four times, with three marriages ending in divorce. He married Joy Stampler, whose son from a previous relationship died of an opioid overdose in 2003. Stampler Fishman had no idea that naloxone existed or that carrying it would have saved her son, let alone that her current husband had helped invent the medication. Stampler Fishman described the incident as "the irony of my life."https://www.cbc.ca/radio/thecurrent/the-current-for-january-2-2019-1.4954395/her-husband-invented-naloxone-her-son-died-from-overdose-now-she-advocates-for-harm-reduction-1.4963056


Career

Fishman studied chemistry at
Yeshiva University Yeshiva University is a private Orthodox Jewish university with four campuses in New York City."About YU
on the Yeshiva Universi ...
, graduating in 1950. He received a master’s degree from
Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
two years later and a doctorate in chemistry in 1955 from
Wayne State University Wayne State University (WSU) is a public research university in Detroit, Michigan. It is Michigan's third-largest university. Founded in 1868, Wayne State consists of 13 schools and colleges offering approximately 350 programs to nearly 25,000 ...
in
Detroit, Michigan Detroit ( , ; , ) is the largest city in the U.S. state of Michigan. It is also the largest U.S. city on the United States–Canada border, and the seat of government of Wayne County. The City of Detroit had a population of 639,111 at ...
. He later worked at the Sloan-Kettering Institute for Cancer Research, as it was known then, but also worked part time at a private pharmaceutical lab run by Mozes J. Lewenstein. Together, they developed and patented naloxone in 1961, which was approved by the Food and Drug Administration in 1971. Fishman is also known for his research on steroids and
estrogen Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal ac ...
, including the role it can play in
breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a r ...
development. He taught at the Albert Einstein College of Medicine of Yeshiva University and served as director of the Institute for Steroid Research at Montefiore Medical Center in the Bronx. He became director of the biochemical endocrinology lab at Rockefeller University and served as director of research at the Strang-Cornell Institute for Cancer Research until relatively recent to his death. He became president of the Miami, Florida pharmaceutical firm Ivax Corporation and was a consultant to the World Health Organization and the National Science Foundation.


References

1930 births 2013 deaths American medical researchers Jewish American scientists 21st-century American Jews {{US-scientist-stub