JWH-424 is a drug from the
naphthoylindole family, which acts as a
cannabinoid agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
at both the
CB1 and
CB2 receptors, but with moderate selectivity for CB
2, having a
Ki of 5.44nM at CB
2 vs 20.9 nM at CB
1. The heavier 8-
iodo analogue is even more CB
2 selective, with its 2-methyl derivative having 40 times selectivity for CB
2. However the 1-propyl homologues in this series showed much lower affinity at both receptors, reflecting a generally reduced affinity for the 8-substituted naphthoylindoles overall.
In the United States, all CB
1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-424 are
Schedule I Controlled Substances.
See also
*
JWH-018
*
JWH-398
JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3 nM and 2.8 nM at CB2. This synthetic chemical comp ...
References
Naphthoylindoles
JWH cannabinoids
Bromoarenes
Designer drugs
CB1 receptor agonists
{{cannabinoid-stub