JWH-210 is an
analgesic
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...
chemical from the
naphthoylindole
Naphthoylindoles are a class of synthetic cannabinoids.
See also
* Structural scheduling of synthetic cannabinoids To combat the illicit synthetic cannabinoid industry many jurisdictions have created a system to control these cannabinoids through ...
family, which acts as a potent
cannabinoid
Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tet ...
agonist at both the
CB1 and
CB2 receptors, with K
i values of 0.46 nM at CB
1 and 0.69 nM at CB
2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher
binding affinity
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a mol ...
(i.e. lower K
i) at CB
1 than both its 4-methyl and 4-''n''-propyl
homologues
JWH-122
JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is a methylated analogue of JWH-018. It has a Ki of 0.69 nM at CB1 and 1.2 nM at CB2.
In January 2015, over 40 people were reportedly sickened after eating a holid ...
(CB
1 K
i 0.69 nM) and JWH-182 (CB
1 K
i 0.65 nM) respectively, and than the 4-methoxy compound
JWH-081
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype is measured at ap ...
(CB
1 K
i 1.2 nM). It was discovered by and named after
John W. Huffman
John William Huffman (1932–2022) was a professor of organic chemistry at Clemson University who first synthesised novel cannabinoids. His research, funded by the National Institute on Drug Abuse, was focused on making a drug to target endocanna ...
.
JWH-210 may be neurotoxic to animals when administered in high doses.
Legal status
In the United States, all CB
1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-210 are
Schedule I Controlled Substance
This is the list of Schedule I drugs as defined by the United States Controlled Substances Act. 21 CFRbr>1308.11(CSA Sched I) with changes through (Oct 18, 2012). Retrieved September 6, 2013. The following findings are required for drugs to be pl ...
s.
JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal"
synthetic cannabis
Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach. These novel psychoactive substances should not be confused with synthetic ...
products. The substances JWH-210, JWH-122 and
JWH-203
JWH-203 (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0 nM at ...
were classified as illegal drugs by the Swedish government as of 1 September 2011.
As of October 2015 JWH-210 is a controlled substance in China.
See also
*
JWH-081
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype is measured at ap ...
*
JWH-193
JWH-193 is a drug from the aminoalkylindole and naphthoylindole families which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-193 has a binding affinity at the CB1 r ...
*
JWH-398
JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3 nM and 2.8 nM at CB2. This synthetic chemical comp ...
References
{{Cannabinoids
JWH cannabinoids
Naphthoylindoles
Designer drugs
CB1 receptor agonists
CB2 receptor agonists