Lysine-specific demethylase 5D is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''KDM5D''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
KDM5D belongs to the
alpha-ketoglutarate-dependent hydroxylases superfamily.
This gene encodes a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
containing
zinc finger domains. A short peptide derived from this protein is a
minor histocompatibility antigen
Minor histocompatibility antigen (also known as MiHA) are receptors on the cellular surface of donated organs that are known to give an immunological response in some organ transplants. They cause problems of rejection less frequently than those of ...
which can lead to graft rejection of male donor cells in a female recipient.
References
Further reading
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External links
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Transcription factors
Human 2OG oxygenases
EC 1.14.11
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