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The J. Craig Venter Institute (JCVI) is a
non-profit A nonprofit organization (NPO) or non-profit organisation, also known as a non-business entity, not-for-profit organization, or nonprofit institution, is a legal entity organized and operated for a collective, public or social benefit, in co ...
genomics Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dim ...
research Research is "creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization and analysis of evidence to increase understanding of a topic, characterized by a particular attentiveness ...
institute founded by J. Craig Venter, Ph.D. in October 2006. The institute was the result of consolidating four organizations: the Center for the Advancement of Genomics, The Institute for Genomic Research (TIGR), the Institute for Biological Energy Alternatives, and the J. Craig Venter Science Foundation Joint Technology Center. It has facilities in Rockville,
Maryland Maryland ( ) is a state in the Mid-Atlantic region of the United States. It shares borders with Virginia, West Virginia, and the District of Columbia to its south and west; Pennsylvania to its north; and Delaware and the Atlantic Ocean t ...
and
La Jolla La Jolla ( , ) is a hilly, seaside neighborhood within the city of San Diego, California, United States, occupying of curving coastline along the Pacific Ocean. The population reported in the 2010 census was 46,781. La Jolla is surrounded on ...
,
California California is a state in the Western United States, located along the Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the most populous U.S. state and the 3rd largest by area. It is also the m ...
. The institute studies the societal implications of genomics in addition to genomics itself. The institute's research involves genomic medicine; environmental genomic analysis;
clean energy Clean may refer to: * Cleaning, the process of removing unwanted substances, such as dirt, infectious agents, and other impurities, from an object or environment * Cleanliness, the state of being clean and free from dirt Arts and media Music A ...
;
synthetic biology Synthetic biology (SynBio) is a multidisciplinary area of research that seeks to create new biological parts, devices, and systems, or to redesign systems that are already found in nature. It is a branch of science that encompasses a broad ran ...
; and ethics, law, and economics. The institute employs over 200 people, including Nobel laureate Hamilton Smith. It was sold to the
University of California, San Diego The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is ...
in 2022.


History

In 2004, the Center for the Advancement of Genomics (TCAG), the Institute for Biological Energy Alternatives (IBEA) and the J. Craig Venter Institute Joint Technology Center (JTC) were merged and to form the J. Craig Venter Institute (JCVI). In 1992, Craig Venter was a researcher at the
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the lat ...
(NIH). He began The Institute for Genomic Research (TIGR) during the same time and was part of the determination of the human genome. Because of disagreements of how the project was being managed TIGR was excluded from the funding by NIH in 1998. The political, personal, and ethical conflicts of the race between the public and private sectors have been notable. In 1995, the precursor to the J. Craig Venter Institute, TIGR, determined the sequence of ''
Haemophilus influenzae ''Haemophilus influenzae'' (formerly called Pfeiffer's bacillus or ''Bacillus influenzae'') is a Gram-negative, non-motile, coccobacillary, facultatively anaerobic, capnophilic pathogenic bacterium of the family Pasteurellaceae. The bact ...
'', ''
Mycoplasma genitalium ''Mycoplasma genitalium'' (''MG'', commonly known as Mgen) is a sexually transmitted, small and pathogenic bacterium that lives on the mucous epithelial cells of the urinary and genital tracts in humans. Medical reports published in 2007 and 2 ...
'', and ''
Methanococcus jannaschii ''Methanocaldococcus jannaschii'' (formerly ''Methanococcus jannaschii'') is a thermophilic methanogenic archaean in the class Methanococci. It was the first archaeon to have its complete genome sequenced. The sequencing identified many genes ...
''. In 1997, TIGR determined the genome of ''
Borrelia burgdorferi ''Borrelia burgdorferi'' is a bacterial species of the spirochete class in the genus '' Borrelia'', and is one of the causative agents of Lyme disease in humans. Along with a few similar genospecies, some of which also cause Lyme disease, it mak ...
'' (which causes Lyme Disease) . In 1998, TIGR sequenced the genome of ''
Treponema pallidum ''Treponema pallidum'', formerly known as ''Spirochaeta pallida'', is a spirochaete bacterium with various subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. It is transmitted only among humans. It is ...
'' (which causes syphilis). In 1999 TIGR published the sequence of the radioresistant polyextremophile '' Deinococcus radiodurans''. TIGR has sequenced and analyzed more than 50 microbial genomes. TIGR developed the gene finder
GLIMMER In bioinformatics, GLIMMER (Gene Locator and Interpolated Markov ModelER) is used to find genes in prokaryotic DNA. "It is effective at finding genes in bacteria, archea, viruses, typically finding 98-99% of all relatively long protein coding g ...
and the
sequence alignment In bioinformatics, a sequence alignment is a way of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences. Al ...
program MUMmer. In
2001 anthrax attacks The 2001 anthrax attacks, also known as Amerithrax (a portmanteau of "America" and "anthrax", from its FBI case name), occurred in the United States over the course of several weeks beginning on September 18, 2001, one week after the September 11 ...
, TIGR worked with the
National Science Foundation The National Science Foundation (NSF) is an independent agency of the United States government that supports fundamental research and education in all the non-medical fields of science and engineering. Its medical counterpart is the National ...
and the FBI to sequence the strain of ''
Bacillus anthracis ''Bacillus anthracis'' is a gram-positive and rod-shaped bacterium that causes anthrax, a deadly disease to livestock and, occasionally, to humans. It is the only permanent ( obligate) pathogen within the genus '' Bacillus''. Its infection is a ...
'' used in bioterrorism attacks. In June 2000, Venter founded The Center for the Advancement of Genomics (TCAG), a think tank for studying the ethics of human genetics and stem cells research. Also in 2002, Venter founded the Institute for Biological Energy Alternatives (IBEA) to investigate the use of microorganisms to produce alternate fuels (such as hydrogen) and to sequester carbon dioxide. The IBEA began genomic sequencing of environmental microbial populations that might be used. To provide support for these facilities, Venter created the J. Craig Venter Institute Joint Technology Center (JTC), which specialized in high throughput sequencing. To provide administrative and financial support for TIGR, TCAG, IBEA and JTC, Venter created the non-profit J. Craig Venter Science Foundation (JCVSF) to consolidate activities between its affiliated organizations. In 2007, the institute published the first diploid human genome, ''i.e.'' the genome of a single individual (J. Craig Venter) in which both sets of chromosomes were sequenced. In 2010, the institute determined the 1.08 million base pair ''
Mycoplasma mycoides ''Mycoplasma mycoides'' is a bacterial species of the genus ''Mycoplasma'' in the class Mollicutes. This microorganism is a parasite that lives in ruminants. ''Mycoplasma mycoides'' comprises two subspecies, '' mycoides'' and ''capri'', which in ...
'' genome, which was then inserted into a cell to create the first cell with a completely synthetic genome. In April 2022 Venter sold the La Jolla facility to the
University of California, San Diego The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is ...
for $25 million. The university, which already has a very strong genomics program, hopes to absorb most of the institute's faculty and its current research grants. Venter will continue to lead a separate nonprofit research group, also known as the J. Craig Venter Institute.


See also

*
Artificial cell An artificial cell, synthetic cell or minimal cell is an engineered particle that mimics one or many functions of a biological cell. Often, artificial cells are biological or polymeric membranes which enclose biologically active materials. As such ...
* The Institute for Genomic Research *
Global Ocean Sampling Expedition The Global Ocean Sampling Expedition (GOS) is an ocean exploration genome project whose goal is to assess genetic diversity in marine microbial communities and to understand their role in nature's fundamental processes. It was begun as a Sargass ...
* '' Mycoplasma laboratorium'' * Synthetic mycoides


References


External links

*
Comprehensive Microbial Resource
{{authority control Genetics or genomics research institutions Research institutes in Maryland Mycoplasma Research institutes in California La Jolla, San Diego Rockville, Maryland