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The International Neuroinformatics Coordinating Facility
INCF
is an international non-profit organization with the mission to develop, evaluate, and endorse standards and best practices that embrace the principles of Open, FAIR, and Citable neuroscience. INCF also provides training on how standards and best practices facilitate reproducibility and enables the publishing of the entirety of research output, including data and code. INCF was established in 2005 by recommendations of the Global Science Forum working group of the
OECD The Organisation for Economic Co-operation and Development (OECD; french: Organisation de coopération et de développement économiques, ''OCDE'') is an intergovernmental organisation with 38 member countries, founded in 1961 to stimulate e ...
. The INCF is hosted by the
Karolinska Institutet The Karolinska Institute (KI; sv, Karolinska Institutet; sometimes known as the (Royal) Caroline Institute in English) is a research-led medical university in Solna within the Stockholm urban area of Sweden. The Karolinska Institute is consiste ...
in
Stockholm Stockholm () is the Capital city, capital and List of urban areas in Sweden by population, largest city of Sweden as well as the List of urban areas in the Nordic countries, largest urban area in Scandinavia. Approximately 980,000 people liv ...
,
Sweden Sweden, formally the Kingdom of Sweden,The United Nations Group of Experts on Geographical Names states that the country's formal name is the Kingdom of SwedenUNGEGN World Geographical Names, Sweden./ref> is a Nordic country located on ...
. The INCF network comprises institutions, organizations, companies, and individuals active in neuroinformatics, neuroscience, data science, technology, and science policy and publishing. The Network is organized in governing bodies and working groups which coordinate various categories of global neuroinformatics activities that guide and oversee the development and endorsement of standards and best practices, as well as provide training on how standards and best practices facilitate reproducibility and enables the publishing of the entirety of research output, including data and code. The current Directors are Mathew Abrams and Helena Ledmyr, and the Governing Board Chair is Maryann Martone The INCF network aims to promote the application of computational approaches to understanding the brain and to develop the infrastructure required to use computational methods to integrate and analyze diverse data across scales, techniques, and species to understand the brain and positively impact the health and well-being of society.


Background

A key element to successfully understanding the
nervous system In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body. The nervous system detects environmental changes th ...
is the integration of
neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ...
with
information science Information science (also known as information studies) is an academic field which is primarily concerned with analysis, collection, Categorization, classification, manipulation, storage, information retrieval, retrieval, movement, dissemin ...
s. The field that studies the nervous system, neuroscience, has responded to the fantastic challenge of understanding how our brain works with the use of the most sophisticated technologies, from studies on the
genome In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding ge ...
to those on
brain imaging Neuroimaging is the use of quantitative (computational) techniques to study the neuroanatomy, structure and function of the central nervous system, developed as an objective way of scientifically studying the healthy human brain in a non-invasive ...
of behaviour in humans and other species, under different functional states, and at all intervening analytical levels. This effort has resulted in large quantities of data, which are ever increasing at higher levels of complexity. The data produced are heterogeneous, coming from different levels of study and modalities of analysis. To rise to this challenge of integration, and to ensure efficient and maximum use of these data, it is now necessary to develop and create these shared resources: # neuroscience data and knowledge databases; # analytical and modelling tools; and # computational models. This challenge is being met through the merging of neurosciences with information science – the field of neuroinformatics.


History


Genesis

The recommendation to coordinate international efforts in the new field of neuroinformatics was first made in the report on
bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...
elaborated under the aegis of the then OECD Megascience Forum in 1998. Following extensive discussions in the Neuroinformatics Working Group of the Global Science Forum chaired by Dr. Stephen H. Koslow, the proposal to create an International Neuroinformatics Coordinating Council and a system of grant funding for neuroinformatics research was then presented in 2002. This project was endorsed by OECD science ministers at their meeting in January 2004. Sixteen countries (Australia, Canada, China, the Czech Republic, Denmark, Finland, France, Germany, India, Italy, Japan, the Netherlands, Norway, Sweden, Switzerland, the United Kingdom, the United States and Victoria, Australia), as well as the European Commission, then elaborated the working documents that form the legal basis for the INCF and the Programme in International Neuroinformatics (PIN).


Establishment

The conditions laid out for the creation of the INCF were met in July 2005, seven countries (the Czech Republic, Finland, Germany, Norway, Sweden, Switzerland, and the United States) having signed the Understanding document and pledged their financial contribution. A bid to host the INCF Secretariat was launched. Two proposals were received and, as instructed by the Governing Board, on November 3, the OECD convened a panel of experts to review and rank the proposals. The panel assigned the higher ranking to the Swedish proposal, and this recommendation was endorsed by the INCF Governing Board when it met at OECD headquarters on November 28. Following extensive international discussions, the INCF was officially inaugurated in February 2007, with headquarters at th
Karolinska Institute
in Stockholm. INCF promotes collaboration in neuroinformatics and reproducibility in brain research by * providing coordination of global neuroscience infrastructure through the development and endorsement of standards and best practices in support of open and FAIR (Findable Accessible Interoperable Reusable) neuroscience (
FAIR data FAIR data are data which meet principles of findability, accessibility, interoperability, and reusability (FAIR). The acronym and principles were defined in a March 2016 paper in the journal ''Scientific Data'' by a consortium of scientists and ...
) * training researchers, administrators, and students on how neuroinformatics promotes rigor and reproducibility, open and FAIR science and publishing the entirety of their research output: narrative, data, and code * encouraging neuroscience as discipline to move towards FORCE (FAIR, Open, Research-object based, and Citable Ecosystem) * promoting the advancement and continued development of neuroinformatics as a scientific discipline


Key Program deliverables

include * Waxholm Space (WHS), a coordinate-based reference space of the rodent brain * Scalable Brain Atlas, a web-based display engine for brain atlases, imaging data, and topologies * NineML, a general model description language * The Multi-Simulation Coordinator (MUSIC), which allows large-scale neuron simulators and other applications to communicate during runtime * The Neuroimaging Informatics Data Model (NI-DM), a framework for the generation, storage, and query of metadata including provenance information * KnowledgeSpace, a community-based encyclopaedia that links brain research concepts with data, models and literature from around the world * TrainingSpace, an online repository linking neuroinformatics training resources developed both by INCF, our partners, and existing community resources.


See also

* Brain Imaging Data Structure (BIDS) *
Blue Brain Project The Blue Brain Project is a Swiss brain research initiative that aims to create a digital reconstruction of the mouse brain. The project was founded in May 2005 by the Brain and Mind Institute of ''École Polytechnique Fédérale de Lausanne'' (EP ...
*
Budapest Reference Connectome The Budapest Reference Connectome server computes the frequently appearing anatomical brain connections of 418 healthy subjects. It has been prepared from diffusion MRI datasets of the Human Connectome Project into a reference connectome (or b ...
*
Human Connectome Project The Human Connectome Project (HCP) is a five-year project sponsored by sixteen components of the National Institutes of Health, split between two consortia of research institutions. The project was launched in July 2009 as the first of three Grand ...
*
List of neuroscience databases A number of online neuroscience databases are available which provide information regarding gene expression, neurons, macroscopic brain structure, and neurological or psychiatric disorders. Some databases contain descriptive and numerical data, som ...
*
Neuroscience Information Framework The Neuroscience Information Framework is a repository of global neuroscience web resources, including experimental, clinical, and translational neuroscience databases, knowledge bases, atlases, and genetic/ genomic resources and provides many aut ...


References


External links

* * Neuroinformatics Congress â€
2019
(Warsaw, Poland)
2018
(Montreal, Canada)
2017201620152014201320122011201020092008

Neuroscience Peer Review Consortium
* {{authority control Neuroinformatics Computational neuroscience Neuroscience organizations