Ivan Maurice Roitt (born 30 September 1927) is a British scientist. He was educated at

King Edward's School, Birmingham King Edward's School (KES) is an independent school (UK), independent day school for boys in the British Public school (UK), public school tradition, located in Edgbaston, Birmingham. Founded by Edward VI of England, King Edward VI in 1552, it ...

and

Balliol College Balliol College () is one of the constituent colleges of the University of Oxford in England. One of Oxford's oldest colleges, it was founded around 1263 by John I de Balliol, a landowner from Barnard Castle in County Durham, who provided the f ...

Oxford University Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the ...

. He was Head of the Department of Immunology at

University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = ...

from 1967 to 1992, and is currently Honorary Director of the Centre for Investigative & Diagnostic Oncology at

Middlesex University Middlesex University London (legally Middlesex University and abbreviated MDX) is a public research university in Hendon, northwest London, England. The name of the university is taken from its location within the historic county boundaries ...

, London, and is related to multi-award winning radio producer Colin Roitt. In 1956, together with

Deborah Doniach Deborah Doniach MD FRCP ( Abileah; 6 April 1912 – 1 January 2004) was a British clinical immunologist and pioneer in the field of autoimmune diseases. Early and personal life Deborah Abileah was born in Geneva, Switzerland, on 6 April 1912 ...

and Peter Campbell, he made the classic discovery of

thyroglobulin Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment o ...

autoantibodies An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases (notably lupus erythematosus) are associated with such antibodies. Pr ...

Hashimoto's thyroiditis Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto's disease, is an autoimmune disease in which the thyroid gland is gradually destroyed. Early on, symptoms may not be noticed. Over time, the thyroid may enlarg ...

which helped to open the whole concept of a relationship between

autoimmunity In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. Any disease resulting from this type of immune response is termed an "autoimmune disease". ...

and human disease. The work was extended to an intensive study of autoimmune phenomena in

pernicious anemia Pernicious anemia is a type of vitamin B12 deficiency anemia, a disease in which not enough red blood cells are produced due to the malabsorption of vitamin B12. Malabsorption in pernicious anemia results from the lack or loss of intrinsic fa ...

and primary biliary

cirrhosis Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is the impaired liver function caused by the formation of scar tissue known as fibrosis due to damage caused by liver disease. Damage causes tissue repai ...

. In 1983 he was elected a Fellow of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

, and has been elected to Honorary Membership of the

Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...

and appointed Honorary Fellow of The

Royal Society of Medicine The Royal Society of Medicine (RSM) is a medical society in the United Kingdom, headquartered in London. History The Society was established in 1805 as Medical and Chirurgical Society of London, meeting in two rooms in barristers’ chambers ...

. He was awarded the

Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a p ...

in 1964. He is an honorary member of the

British Society for Immunology The British Society for Immunology, or BSI, is a UK-based organisation of British immunologists but accepts members from all countries. It was founded in November 1956 by John H. Humphrey, Robin Coombs, Bob White, and Avrion Mitchison and is one ...

References

External links

*http://www.roitt.com/ * 1927 births British Jews British biochemists Jewish scientists Fellows of the Royal Society Possibly living people Alumni of Balliol College, Oxford People educated at King Edward's School, Birmingham Academics of University College London {{UK-biochemist-stub