''Spica'' has been borne by at least four ships of the Italian Navy and may refer to:
* , a launched in 1905 and discarded in 1923.
* , a launched in 1934. Sold to Sweden in 1940 and renamed HSwMS ''Romulus''. Decommissioned in 1958.
* , an captured before launch by Germany in 1943. She was renamed ''TA45'' and launched in 1944. Sunk in 1945.
* , a launched in 1989.
{{DEFAULTSORT:Spica, Italian ship
Italian Navy ship names