Isoquercetin, isoquercitrin or isotrifoliin is a

flavonoid Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans. Chemically, flavonoids ...

, a type of chemical compound. It is the 3-''O''-

glucoside A glucoside is a glycoside that is derived from glucose. Glucosides are common in plants, but rare in animals. Glucose is produced when a glucoside is hydrolysed by purely chemical means, or decomposed by fermentation or enzymes. The name was o ...

quercetin Quercetin is a plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions, and kale are common foods containing appreciable amounts of it. It has a bitter flavor a ...

. Isoquercitrin can be isolated from various plant species including ''

Mangifera indica ''Mangifera indica'', commonly known as mango, is a species of flowering plant in the family Anacardiaceae. It is a large fruit tree, capable of growing to a height of . There are two distinct genetic populations in modern mangoesthe "Indian type ...

'' (

mango A mango is an edible stone fruit produced by the tropical tree ''Mangifera indica''. It is believed to have originated in the region between northwestern Myanmar, Bangladesh, and northeastern India. ''M. indica'' has been cultivated in South a ...

) and ''

Rheum nobile ''Rheum nobile'', the Sikkim rhubarb or noble rhubarb or पदमचाल, is a giant herbaceous plant native to the Himalaya, from northeastern Afghanistan, east through northern Pakistan and India, Nepal, Sikkim (in India), Bhutan, and Tib ...

'' (the Noble rhubarb). It is also present in the leaves of ''

Annona squamosa ''Annona squamosa'' is a small, well-branched tree or shrub from the family Annonaceae that bears edible fruits called sugar-apples or . It tolerates a tropical lowland climate better than its relatives ''Annona reticulata'' and ''Annona cherimo ...

'', ''

Camellia sinensis ''Camellia sinensis'' is a species of evergreen shrub or small tree in the flowering plant family Theaceae. Its leaves and leaf buds are used to produce the popular beverage, tea. Common names include tea plant, tea shrub, and tea tree (not to ...

'' (

tea Tea is an aromatic beverage prepared by pouring hot or boiling water over cured or fresh leaves of '' Camellia sinensis'', an evergreen shrub native to East Asia which probably originated in the borderlands of southwestern China and northe ...

). and ''

Vestia foetida ''Vestia'' is a monotypic genusLas Penas, M. L., et al. (2006)Karyotypes of some species of ''Cestrum'', ''Sessea'', and ''Vestia'' (tribe Cestreae, Solanaceae).''Caryologia'' 59(2) 131-37. of flowering plants in the family Solanaceae containing ...

Spectral data

The lambda-max for isoquercetin is 254.8 and 352.6 nm.

Potential clinical uses

Isoquercetin is presently being investigated for prevention of

thromboembolism Thrombosis (from Ancient Greek "clotting") is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel (a vein or an artery) is injured, the body uses platelets (thro ...

in selected cancer patients and as an anti-

fatigue Fatigue describes a state of tiredness that does not resolve with rest or sleep. In general usage, fatigue is synonymous with extreme tiredness or exhaustion that normally follows prolonged physical or mental activity. When it does not resolve ...

agent in kidney cancer patients treated with

sunitinib Sunitinib, sold under the brand name Sutent, is a medication used to treat cancer. It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and i ...

. There is a single case report of its use in the successful treatment of

prurigo nodularis Prurigo nodularis (PN), also known as nodular prurigo, is a skin disease characterised by pruritic (itchy) nodules which usually appear on the arms or legs. Patients often present with multiple excoriated lesions caused by scratching. PN is also k ...

, a difficult to treat pruritic eruption of the skin. However it belongs to the PAINS (Pan-assay interference compounds) categories of chemicals.

Spectral data

Potential clinical uses

References

See also