Isofurans are
nonclassic eicosanoids formed nonenzymatically by free radical mediated peroxidation of
arachidonic acid
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6), or 20:4(5,8,11,14). It is structurally related to the saturated arachidic acid found in cupuaçu butter. Its name derives from the New Latin word ''arachi ...
. The isofurans are similar to the
isoprostanes and are formed under similar conditions, but contain a substituted
tetrahydrofuran ring. The concentration of oxygen affects this process; at elevated oxygen concentrations, the formation of isofurans is favored whereas the formation of isoprostanes is disfavored.
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References
Eicosanoids
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