Isoconazole is an
azole
Azoles are a class of five-membered heterocyclic compounds containing a nitrogen atom and at least one other non-carbon atom (i.e. nitrogen, sulfur, or oxygen) as part of the ring.
Their names originate from the Hantzsch–Widman nomenclature. T ...
antifungal drug
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryp ...
and could inhibit gram positive bacteria.
For foot and vaginal infections, isoconazole has a similar effectiveness to
clotrimazole
Clotrimazole, sold under the brand name Lotrimin, among others, is an antifungal medication. It is used to treat vaginal yeast infections, oral thrush, diaper rash, tinea versicolor, and types of ringworm including athlete's foot and jock itch ...
.
Isoconazole nitrate may be used in combination with
corticosteroid
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involv ...
diflucortolone
Diflucortolone (INN), or difluocortolone, is a corticosteroid
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of cort ...
to increase its
bioavailability
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.
By definition, when a medication is administered intravenously, its bioavailability is 100%. H ...
.
[
It was patented in 1968 and approved for medical use in 1979.]
References
21-Hydroxylase inhibitors
Aromatase inhibitors
Chloroarenes
CYP17A1 inhibitors
Phenylethanolamine ethers
Imidazole antifungals
Lanosterol 14α-demethylase inhibitors
{{genito-urinary-drug-stub