Isoorientin (or homoorientin) is a
flavone, a chemical flavonoid-like compound. It is the luteolin-6-C-glucoside.
Bioassay-directed fractionation
Fractionation is a separation process in which a certain quantity of a mixture (of gases, solids, liquids, enzymes, or isotopes, or a suspension) is divided during a phase transition, into a number of smaller quantities (fractions) in which th ...
techniques led to isolation of isoorientin as the main
hypoglycaemic component in ''
Gentiana olivieri
''Gentiana olivieri'' (Chinese: xie wan que qin jiao) is a plant species in the genus ''Gentiana
''Gentiana'' is a genus of flowering plants belonging to the gentian family (Gentianaceae), the tribe Gentianeae, and the monophyletic subtr ...
''. Studies also showed that isoorientin is a potential
neuroprotective
Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...
compound against
Alzheimer's disease.
Natural occurrences
Isoorientin can be isolated from the
passion flower
''Passiflora'', known also as the passion flowers or passion vines, is a genus of about 550 species of flowering plants, the type genus of the family Passifloraceae.
They are mostly tendril-bearing vines, with some being shrubs or trees. The ...
, ''
Vitex negundo
''Vitex negundo'', commonly known as the Chinese chaste tree, five-leaved chaste tree, or horseshoe vitex, or nisinda is a large aromatic shrub with quadrangular, densely whitish, tomentose branchlets. It is widely used in folk medicine, par ...
'', ''
Terminalia myriocarpa
''Terminalia myriocarpa'', the East Indian almond, is a tree species in the genus '' Terminalia'' found in Southeast Asia.
Ecology
The larvae of the moth '' Acrocercops terminaliae'' feed on ''T. myriocarpa''.
Chemistry
The phenolic compounds ...
'', the
Açaí palm
The açaí palm (, , from Nheengatu ''asai''), '' Euterpe oleracea,'' is a species of palm tree (Arecaceae) cultivated for its fruit (açaí berries, or simply açaí), hearts of palm (a vegetable), leaves, and trunk wood. Global demand for t ...
and ''
Swertia japonica''.
Metabolism
*
Isoorientin 3'-O-methyltransferase
In enzymology, an isoorientin 3'-O-methyltransferase () is an enzyme that catalyzes the chemical reaction
:S-adenosyl-L-methionine + isoorientin \rightleftharpoons S-adenosyl-L-homocysteine + isoscoparin
Thus, the two substrates of this enzyme ...
See also
*
Orientin
Orientin is a flavone, a chemical flavonoid-like compound. It is the 8-C glucoside of luteolin.
Natural occurrences
Orientin is found in ''Adonis vernalis'', in '' Anadenanthera colubrina'' and ''Anadenanthera peregrina'', and in the '' Phyllost ...
, the 8-C
glucoside of
luteolin
Luteolin is a flavone, a type of flavonoid, with a yellow crystalline appearance.
Luteolin is the principal yellow dye compound that is obtained from the plant '' Reseda luteola'', which has been used as a source of the dye since at least the f ...
.
References
Flavone glucosides
C-glycoside natural phenols
{{aromatic-stub