Invasive Lobular Carcinoma on:
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Invasive lobular carcinoma (ILC) is
File:Histopathology of invasive lobular carcinoma, next to lobular carcinoma in situ, annotated.jpg, Histopathology of invasive lobular carcinoma (ILC), next to lobular carcinoma in situ (LCIS)
File:Breast invasive lobular carcinoma (2).jpg, Invasive lobular carcinoma demonstrating a predominantly lobular growth pattern
File:LobularBreastCancer.jpg, Lobular breast cancer. Single file cells and cell nests.
Invasive lobular carcinoma (ILC) is breast cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a r ...
arising from the lobules of the mammary glands
A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring. Mammals get their name from the Latin word ''mamma'', "breast". The mammary glands are arranged in organs such as the breasts in prima ...
. It accounts for 5–10% of invasive breast cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a r ...
. Rare cases of this carcinoma have been diagnosed in men (see male breast cancer
Male breast cancer (MBC) is a cancer in males that originates in their breasts. Males account for less than 1% of new breast cancers with about 20,000 new cases being diagnosed
worldwide every year. Its incidence rates in males vs. females are, ...
).
Types
The histologic patterns include:Fletcher's diagnostic histopathology of tumors. 3rd Ed. p. 931-932.Prognosis
Overall, the five-year survival rate of invasive lobular carcinoma was approximately 85% in 2003.Diagnosis
On mammography, ILC shows spiculated mass with ill-defined margins that has similar or lower density than surrounding breast tissues. This happens only at 44–65% of the time. Architectural distortion on surrounding breast tissues is only seen in 10–34% of the cases. It can be reported as benign in 8–16% of the mammography cases. Ultrasound has 68–98% sensitivity of detecting ILC. ILC shows irregular or angular mass with hypoechoic or heterogenous internal echoes, ill-defined or spiculated margins, and posterior acoustic shadowin. Loss ofE-cadherin
Cadherin-1 or Epithelial cadherin (E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the ''CDH1'' gene. Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian ...
is common in lobular carcinoma but is also seen in other breast cancers.Treatment
Treatment includes surgery and adjuvant therapy.References
External links
{{Epithelial neoplasms Breast cancer