Interstate 80S may refer to:
* The former name of
Interstate 76 (Colorado–Nebraska)
Interstate 76 (I-76) is an east–west Interstate Highway in the Western United States that runs from I-70 in Arvada, Colorado – near Denver – to an intersection with I-80 near Big Springs, Nebraska. The highway me ...
, an Interstate Highway in Colorado and Nebraska in the United States, until 1975
* The former name of
Interstate 76 (Ohio–New Jersey), an Interstate Highway in Ohio, Pennsylvania, and New Jersey in the United States, until 1972
{{road disambiguation
80S
Interstate 80