Interstate 375 may refer to:
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Interstate 375 (Florida)
Interstate 375 (I-375) in St. Petersburg, Florida, also known as North Bay Drive, is a spur route from I-275 into downtown. It is also designated as the unsigned State Road 592 (SR 592). There is a sibling segment of freeway nea ...
, a spur in St. Petersburg, Florida
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Interstate 375 (Michigan), a spur in Detroit, Michigan
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