Interstate 295 is the designation for several Interstate Highways in the United States:
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Interstate 295 (Delaware–Pennsylvania), a bypass of Philadelphia, Pennsylvania
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Interstate 295 (Florida), a beltway around central Jacksonville
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Interstate 295 (Maine), an alternate route through and north of Portland
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Interstate 295 (Maryland–District of Columbia), a connector route in Washington, D.C.
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Interstate 295 (New York), a connector route in Queens and Bronx counties
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Interstate 295 (North Carolina), a partially complete bypass of Fayetteville
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Interstate 295 (Rhode Island–Massachusetts), a bypass of Providence, Rhode Island
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Interstate 295 (Virginia), a bypass of Richmond and Petersburg
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