Interstate 275 (I-275) may refer to:
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Interstate 275 (Florida), a loop through Tampa, St. Petersburg, and Bradenton in Florida
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Interstate 275 (Michigan), a western bypass of Detroit, Michigan
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Interstate 275 (Ohio–Indiana–Kentucky)
Interstate 275 (I-275) is an highway in Ohio, Indiana, and Kentucky that forms a complete beltway around the Cincinnati metropolitan area and includes a part in a state (Indiana) not entered by the parent route. It had been the only aux ...
, a full beltway around Cincinnati, Ohio
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Interstate 275 (Tennessee), a connection to downtown Knoxville, Tennessee, from the north
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