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An interolog is a conserved interaction between a pair of
Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:
*A is a homolog of A'. (Protein homologs have similar
Interactome.org
Interactome portal site.
Interactomics.org
Interactomics portal site.
Cross-species interaction prediction site. Protein complexes Bioinformatics {{bioinformatics-stub
proteins
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
which have interacting homologs
A couple of homologous chromosomes, or homologs, are a set of one maternal and one paternal chromosome that pair up with each other inside a cell during fertilization. Homologs have the same genes in the same locus (genetics), loci where they pr ...
in another organism. The term was introduced in a 2000 paper by Walhout et al.
Example
Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:
*A is a homolog of A'. (Protein homologs have similar amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha am ...
sequences and derive from a common ancestral sequence).
*B is a homolog of B'.
*A and B interact.
*A' and B' interact.
Thus, interologs are homologous pairs of protein interactions across different organisms.
See also
*Homology (biology)
In biology, homology is similarity due to shared ancestry between a pair of structures or genes in different taxa. A common example of homologous structures is the forelimbs of vertebrates, where the wings of bats and birds, the arms of pri ...
*Systems biology
Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological syst ...
*Bioinformatics
Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...
References
* * *External links
Interactome.org
Interactome portal site.
Interactomics.org
Interactomics portal site.
Cross-species interaction prediction site. Protein complexes Bioinformatics {{bioinformatics-stub