The internal elastic lamina or internal elastic lamella is a layer of elastic tissue that forms the outermost part of the

tunica intima The tunica intima (New Latin "inner coat"), or intima for short, is the innermost tunica (layer) of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in ...

of blood vessels. It separates tunica intima from

tunica media The tunica media (New Latin "middle coat"), or media for short, is the middle tunica (layer) of an artery or vein. It lies between the tunica intima on the inside and the tunica externa on the outside. Artery Tunica media is made up of smooth m ...

Histology

It is readily visualized with light microscopy in sections of muscular arteries, where it is thick and prominent, and

arterioles An arteriole is a small-diameter blood vessel in the microcirculation that extends and branches out from an artery and leads to capillaries. Arterioles have muscular walls (usually only one to two layers of smooth muscle cells) and are the primar ...

, where it is slightly less prominent and often incomplete. It is very thin in veins and venules. In

elastic arteries An elastic artery (conducting artery or conduit artery) is an artery with many collagen and elastin filaments in the tunica media, which gives it the ability to stretch in response to each pulse. This elasticity also gives rise to the Windkessel ...

such as the aorta, which have very regular elastic laminae between layers of

smooth muscle Smooth muscle is an involuntary non-striated muscle, so-called because it has no sarcomeres and therefore no striations (''bands'' or ''stripes''). It is divided into two subgroups, single-unit and multiunit smooth muscle. Within single-unit mus ...

cells in their

, the internal elastic lamina is approximately the same thickness as the other elastic laminae that are normally present.http://www.ouhsc.edu/histology/text%20sections/cardiovascular.html There is small amount of subendothelial connective tissue between

basement membrane The basement membrane is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. The basement membrane sits between Epithelium, epithelial tissues including mesot ...

of endothelial cells and internal elastic lamina. Reduplication of internal elastic lamina can be seen in elderly individuals due to

intimal fibroplasia The tunica intima (New Latin "inner coat"), or intima for short, is the innermost tunica (layer) of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in ...

, which is part of the

aging Ageing ( BE) or aging ( AE) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In ...

process.

Associated pathologic conditions

*Damage in Giant cell arteritis leads to microaneurysms. Demonstration of fragmentation in this layer by elastin-

van Gieson Van Gieson's stain is a mixture of picric acid and acid fuchsin. It is the simplest method of differential staining of collagen and other connective tissue. It was introduced to histology by American neuropsychiatrist and pathologist Ira Van ...

stain aids in diagnosis of

giant cell arteritis Giant cell arteritis (GCA), also called temporal arteritis, is an inflammatory autoimmune disease of large blood vessels. Symptoms may include headache, pain over the temples, flu-like symptoms, double vision, and difficulty opening the mouth. ...

. It stains

muscle Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscl ...

tissue in yellow,

connective tissue Connective tissue is one of the four primary types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue. It develops from the mesenchyme derived from the mesoderm the middle embryonic germ layer. Connective tiss ...

in red and elastic structures (like internal elastic lamina) in black color. * In chronic allograft nephropathy, disruption or reduplication of internal elastic lamina can be observed, which causes narrowing of the lumen and downstream ischemia. * In fungal

rhinosinusitis Rhinosinusitis is a simultaneous infection of the nasal mucosa (rhinitis) and an infection of the mucosa of the paranasal sinuses (sinusitis). A distinction is made between acute rhinosinusitis and chronic rhinosinusitis. Background Because sinu ...

, the organism has predilection for internal elastic lamina during phase of spread.

References

Angiology {{circulatory-stub