Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the RAS, ICBFM SB RAS (russian: link=no, Институт химической биологии и фундаментальной медицины СО РАН, ИХБФМ СО РАН) is a research institute in

Novosibirsk Novosibirsk (, also ; rus, Новосиби́рск, p=nəvəsʲɪˈbʲirsk, a=ru-Новосибирск.ogg) is the largest city and administrative centre of Novosibirsk Oblast and Siberian Federal District in Russia. As of the Russian Census ...

, Russia. It was founded in 1984.

History

The Institute of Chemical Biology and Fundamental Medicine (formerly the Novosibirsk Institute of Bioorganic Chemistry) was founded on 1 April 1984.В TikTok появится цикл научно-популярных роликов о генетике. ТАСС.
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Scientific activity

Creation of gene-targeted biological preparations, developments in the field of

gene therapy Gene therapy is a medical field which focuses on the genetic modification of cells to produce a therapeutic effect or the treatment of disease by repairing or reconstructing defective genetic material. The first attempt at modifying human DN ...

, the study of physical and chemical processes of transmission and preservation of hereditary information.

Test system for detection of SARS-CoV-2 Omicron variant

At the end of 2021, the staff of the ICBFM SB RAS, together with scientists from

Saint Petersburg Saint Petersburg ( rus, links=no, Санкт-Петербург, a=Ru-Sankt Peterburg Leningrad Petrograd Piter.ogg, r=Sankt-Peterburg, p=ˈsankt pʲɪtʲɪrˈburk), formerly known as Petrograd (1914–1924) and later Leningrad (1924–1991), i ...

, created a test system that simultaneously detects the presence of the genetic material of the coronavirus and determines whether it belongs to the omicron strain.

Method for inactivating the CRISPR/Cas9 genome editing system at a specific point in time

The CRISPR/Cas9 genome editing was discovered by molecular biologists

Jennifer Doudna Jennifer Anne Doudna (; born February 19, 1964) is an American biochemist who has done pioneering work in CRISPR gene editing, and made other fundamental contributions in biochemistry and genetics. Doudna was one of the first women to share a ...

(United States) and

Emmanuelle Charpentier Emmanuelle Marie Charpentier (; born 11 December 1968) is a French professor and researcher in microbiology, genetics, and biochemistry. As of 2015, she has been a director at the Max Planck Institute for Infection Biology in Berlin. In 2018, sh ...

(France), thanks to which they received the Nobel Prize.Сибирские ученые изобрели способ выключить систему редактирования генома в нужный момент. Наука в Сибири.
/ref> Scientists at the ICBFM SB RAS have developed a method to inactivate the CRISPR/Cas9 genome editing system at a specific point in time. In 2022, the institute received a patent for the invention – ''Modified guide RNA which has the ability to inactivate the CRISPR/Cas9 genome editing system, and method for obtaining it'' (''Модифицированная направляющая РНК, обладающая способностью инактивировать систему редактирования генома CRISPR/Cas9, и способ ее получения'').

References

{{coord, 54.8504, 83.1044, type:landmark_region:RU, display=title Research institutes in Novosibirsk 1984 establishments in the Soviet Union Research institutes established in 1984 Medical research institutes in the Soviet Union Genetics or genomics research institutions Institutes of the Russian Academy of Sciences