Insert Therapeutics, Inc., now Calando Pharmaceuticals, Inc., is a

medical research Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from "basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientif ...

company that uses

nanobiotechnology Nanobiotechnology, bionanotechnology, and nanobiology are terms that refer to the intersection of nanotechnology and biology. Given that the subject is one that has only emerged very recently, bionanotechnology and nanobiotechnology serve as blan ...

specializing in therapeutic agents that are conjugated, to facilitate and enhance drug delivery. The small company was founded in 2000, is located in

Pasadena, California Pasadena ( ) is a city in Los Angeles County, California, northeast of downtown Los Angeles. It is the most populous city and the primary cultural center of the San Gabriel Valley. Old Pasadena is the city's original commercial district. I ...

, and is owned by Arrowhead Research Corporation. The conjugates consist of a cyclodextrin-containing polymer (Cyclosert) that acts as a drug delivery system, and a linked medication, such as a chemotherapeutic drug of already proven efficacy.IT-101 trial
/ref> The size of the polymer is designed to “fit” the specific target, as vessels in a neoplasm allow for leakage of different sizes of polymers, as in healthy tissue. The leaked conjugates are concentrated in the target area. As a result, chemotherapeutic activity is locally enhanced, while general side effects are decreased. At least one of their conjugates, IT-101, has been investigated in a

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

at City of Hope National Medical Center.

References

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External links

Calando Pharmaceuticals, Inc.
was Insert Therapeutics, Inc.
Cerulean Pharma, Inc.
IT-101 licensee Biotechnology companies of the United States