In Vivo Supersaturation
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In vivo supersaturation is the behavior of orally administered compounds that undergo
supersaturation In physical chemistry, supersaturation occurs with a solution when the concentration of a solute exceeds the concentration specified by the value of solubility at equilibrium. Most commonly the term is applied to a solution of a solid in a liqu ...
as they pass through the gastrointestinal (GI) tract. Typically these compounds have a weakly basic nature ( p''K''a in the range of 5 to 8) and a relatively low solubility in aqueous solutions. In vivo supersaturation is a recent phenomenon that was first observed by Yamashita et al. in 2003.


References

Pharmacodynamics {{pharma-stub