The Immune Epitope Database and Analysis Resource (IEDB) is a project hosted by scientists at the La Jolla Institute for Allergy and Immunology (LIAI), with support from th
(NIAID), a part of th
{Dead link, date=January 2020 , bot=InternetArchiveBot , fix-attempted=yes (NIH), an
Department of Health and Human Services(HHS). The focus is dissemination of immune epitope information to facilitate the generation of new research tools, diagnostic techniques, vaccines and therapeutics.
Database
The IEDB contains data related to
antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...
and
T cell
A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell r ...
epitopes
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The epitope is the specific piece of the antigen to which an antibody binds. The p ...
for humans, non-human primates, rodents, and other animal species. Curation of data relating t
NIAID Category A, B, and C priority pathogens(including Influenza) an
is of highest priority and is being continuously updated. In addition, epitopes from other
infectious agents,
allergens
An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body. Such reactions are called allergies.
In technical terms ...
and
autoantigens are being curated.
The database also contains
MHC binding data from a variety of different antigenic sources and immune epitope data from the FIMM (Brusic),
HLA Ligand (Hildebrand), TopBank (Sette), and MHC binding (Buus) databases. These databases and their investigators are hereby acknowledged as major contributors to the IEDB.
Tools
In addition to the database, the IEDB website hosts an Analysis Resource, which contains a collection of tools to predict and analyze epitopes.
External links
Immune Epitope Database IEDB Analysis Resource
*La Jolla Institute for Allergy and Immunology
La Jolla Institute for Immunology is a non-profit research organization located in La Jolla, California. It is located in UC San Diego’s Research Park. The institute researches immunology and immune system diseases. The institute employs 220 M.D ...
Medical databases