Imiloxan is a drug which is used in

scientific research The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific m ...

. It acts as a selective antagonist for the α_2B adrenergic receptor, and has been useful for distinguishing the actions of the different α₂ adrenergic subtypes.

Synthesis

The

imidazole Imidazole (ImH) is an organic compound with the formula C3N2H4. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole, and has non-a ...

portion of imiloxan is prepared by the reaction of an

imidate Carboximidates (or more general imidates) are organic compounds, which can be thought of as esters formed between a carboximidic acid (R-C(=NR')OH) and an alcohol, with the general formula R-C(=NR')OR". They are also known as imino ethers, sin ...

with the diethyl acetal of aminoacetaldehyde. ''N''-Alkylation of the imidazole with

ethyl iodide Ethyl iodide (also iodoethane) is a colorless flammable chemical compound. It has the chemical formula C2H5I and is prepared by heating ethanol with iodine and phosphorus.''Merck Index of Chemicals and Drugs'', 9th ed., monograph 3753 On contact ...

gives imiloxan.

References

External links

* Imidazolines Alpha blockers Benzodioxans {{antihypertensive-stub